|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
BEFREE |
More recently, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associated SNPs, some of them located in novel genes with no clear role in the haemostatic system, such as SLC44A2 rs2288904 and TSPAN15 rs78707713.
|
31689458 |
2020 |
|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.
|
31676865 |
2019 |
|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
|
31420334 |
2019 |
|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.
|
28373160 |
2017 |
|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.
|
26908601 |
2016 |
|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.
|
25772935 |
2015 |
|
Venous Thromboembolism
|
0.120 |
GeneticVariation
|
phenotype |
BEFREE |
Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.
|
25772935 |
2015 |
|
Pulmonary Embolism
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.
|
26908601 |
2016 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.
|
26908601 |
2016 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.
|
26908601 |
2016 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis.
|
26908601 |
2016 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma.
|
31518558 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we show that high TSPAN15 expression in OSCC tissues is significantly associated with lymph node and distant metastasis, advanced clinical stage, and poor prognosis.
|
29650964 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Tspan15 positive tumors exhibit signatures related to hepatic progenitor cells as well as recurrence of cancer.
|
31390680 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma.
|
31518558 |
2019 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, Tspan15 overexpression in the hepatoma cell line HepG2 significantly increases cell proliferation.
|
31390680 |
2019 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, Tspan15 is a new stemness-related marker in HCC which exhibits high potential of tumor growth and recurrence.
|
31390680 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Significant up-regulated Tspan15 expression was found in the advanced OSCC cases; primary tumoral size (P = 0.042), regional lymph node metastasis (P = 0.036) and TNM classification (P = 0.024).
|
31518558 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Tspan15 positive tumors exhibit signatures related to hepatic progenitor cells as well as recurrence of cancer.
|
31390680 |
2019 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Tspan15 overexpression in the hepatoma cell line HepG2 significantly increases cell proliferation.
|
31390680 |
2019 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, Tspan15 expression was elevated in brains of an Alzheimer's disease mouse model and of patients, suggesting that upregulation of Tspan15 expression reflects a cellular response in a disease state.
|
29520422 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings indicate that TSPAN15 may serve as a new biomarker and/or provide a novel therapeutic target to OSCC patients.
|
29650964 |
2018 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
TSPAN15 and SLC44A2 do not belong to conventional pathways for thrombosis and have not been associated to other cardiovascular diseases nor related quantitative biomarkers.
|
25772935 |
2015 |
|
Transfusion-Related Acute Lung Injury
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The lead SNP at the TSPAN15 locus is the intronic rs78707713 and the lead SLC44A2 SNP is the non-synonymous rs2288904 previously shown to associate with transfusion-related acute lung injury.
|
25772935 |
2015 |