More recently, genome-wide association studies (GWAS) have contributed to the identification of novel VTE-associated SNPs, some of them located in novel genes with no clear role in the haemostatic system, such as SLC44A2 rs2288904 and TSPAN15 rs78707713.
Association tests pointed to single nucleotide polymorphism (SNP) rs201967957 (gene <i>MEIS1</i>; chromosome 2; <i>p</i>-value<sub>IBS</sub> = 3.71 × 10<sup>-13</sup>) and rs576099063 (gene <i>TSPAN15</i>; chromosome 10; <i>p</i>-value<sub>IBS</sub> = 2.36 × 10<sup>-8</sup>) as the best candidate variants associated to pneumococcal pneumonia.
Association tests pointed to single nucleotide polymorphism (SNP) rs201967957 (gene <i>MEIS1</i>; chromosome 2; <i>p</i>-value<sub>IBS</sub> = 3.71 × 10<sup>-13</sup>) and rs576099063 (gene <i>TSPAN15</i>; chromosome 10; <i>p</i>-value<sub>IBS</sub> = 2.36 × 10<sup>-8</sup>) as the best candidate variants associated to pneumococcal pneumonia.
The lead SNP at the TSPAN15 locus is the intronic rs78707713 and the lead SLC44A2 SNP is the non-synonymous rs2288904 previously shown to associate with transfusion-related acute lung injury.