|
Acute anterior uveitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between AU and KIAA1109-rs4505848 or IL27-rs4788084 even stratified by gender.
|
22065918 |
2011 |
|
Acute Chest Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results indicated that IL-27 could be a novel therapeutic target in ACS patients.
|
30631648 |
2019 |
|
Acute Chest Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our data warrants further mechanistic studies to elucidate the involvement of IL-27 in cardiac repair and remodeling after ACS.
|
29428559 |
2019 |
|
Acute Chest Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
However, there was no significant difference in IL-27 levels among 3 groups of ACS, stable CAD, and CAD(-) (0.26, 0.25, and 0.22 ng/mL), whereas hsCRP levels were significantly higher in ACS and stable CAD than in CAD(-) (2.09, 0.91 vs 0.41 mg/L, P < .001) and were highest in ACS.
|
29068992 |
2017 |
|
Acute Coronary Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Changes in interleukin-27 levels in patients with acute coronary syndrome and their clinical significance.
|
30631648 |
2019 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death.
|
29428559 |
2019 |
|
Acute hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-27 regulated CXCR3 ligand expression in IFNγ-dependent manner during acute hepatitis suggesting a complementary role of IL-27 and IFNγ to moderate liver inflammation via regulation of CXCR3 ligands.
|
26199110 |
2015 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Using a persistently replicating rodent pathogen, LCMV, in its natural host, we identified the cellular sources and effects of one important regulatory pathway, interleukin-27 receptor WSX-1 signaling, that is required for both very early and late restriction of chronic (but not acute) infection.
|
29593047 |
2018 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study has evaluated the effects of IL-27 rs153109 and rs17855750 single nucleotide polymorphisms (SNPs) on risk of acute lymphoblastic leukemia (ALL) development, as well as their impact on prognosis and patient survival.
|
28828696 |
2018 |
|
Acute Motor Axonal Neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum IL-27 concentrations were elevated (p=0.002) whereas serum IL-35 concentrations were decreased (p=0.031) in patients with GBS comparing with healthy controls, particularly in patients exhibiting AMAN (p=0.012).
|
28167198 |
2017 |
|
Acute myocardial infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
The incidence of the combined end-point of AMI and cardiovascular death was higher in patients with plasma IL-27 within the top two tertiles both at baseline and after 6 weeks.
|
29428559 |
2019 |
|
Acute myocardial infarction
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Compared to SA patients and healthy controls, patients with ACS (AMI + UA) had lower serum levels of IL-27 and higher proportions of PBMC Th1 and Th17 cells, which could be attributed to the inhibitory effects of IL-27 on the proliferation of Th17 cells.
|
30631648 |
2019 |
|
Acute type B viral hepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL-27 was also detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with acute hepatitis B or chronic hepatitis B (P<0.05).
|
19081304 |
2009 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG levels were positively correlated with IL-27 and may predict prognosis in HBV-ACLF patients.
|
31198792 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
IL-27's effects were tested on Adenocarcinoma (AC) and Squamous Cell Carcinoma (SCC) cell lines and xenograft models.
|
25638163 |
2015 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study has evaluated the effects of IL-27 rs153109 and rs17855750 single nucleotide polymorphisms (SNPs) on risk of acute lymphoblastic leukemia (ALL) development, as well as their impact on prognosis and patient survival.
|
28828696 |
2018 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo.
|
22193967 |
2012 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results strongly encourage the development of future clinical trials to evaluate the toxicity and efficacy of the IL-23 and IL-27 in lymphoma patients.
|
22193967 |
2012 |
|
Adult Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma.
|
27564404 |
2016 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Human T-cell leukemia virus type 2 post-transcriptional control protein p28 is required for viral infectivity and persistence in vivo.
|
18474092 |
2008 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Structural analysis of p28 adult T-cell leukaemia-associated antigen.
|
3014050 |
1986 |
|
Age related macular degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data thus reveal a novel role of IL-27 in regulating complement activation through up-regulation of CFH and suggest that defects in IL-27 signaling or expression may contribute to the reduction of CFH expression in the retina of patients with AMD.
|
23029250 |
2012 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Preventative tracheal administration of interleukin-27 attenuates allergic asthma by improving the lung Th1 microenvironment.
|
30367458 |
2019 |
|
Allergic rhinitis (disorder)
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recombinant IL‑37 (rIL‑37) inhibited the production of IL‑1p and IL‑6, and enhanced the production of IL‑27 in PBMCs from the patients with AR and the control individuals. rIL‑37 also markedly decreased the expression of IL‑17 by CD4+ T cells in the patients with AR and controls.
|
29115624 |
2018 |
|
Allergic rhinitis (disorder)
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
This randomized, placebo-controlled dose-response study was performed to analyze the effects of SLIT on FOXP3, IL-17, IL-23, and IL-27 expressions in peripheral blood mononuclear cells (PBMC) of children with allergic rhinitis and their associations with clinical outcome.
|
19566585 |
2010 |