|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
We also examined the potential of IL-27 gene delivery by sonoporation to treat and reduce the growth of prostate cancer in vivo.
|
21801027 |
2011 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
Here, we asked whether IL30 may favor prostate cancer progression by conditioning PCSLCs and assessed the value of blocking IL30 to suppress tumor growth.
|
29487200 |
2018 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
Taken together, this study demonstrates a potential role for IL-27 in the treatment of prostate cancer.
|
31009295 |
2019 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
IL-30 silencing in PC-SLCs prevented lung metastasis in 73% of tumor-bearing WT mice and up to 80% in tumor-bearing IL-30KO mice.
|
31366386 |
2019 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
We, thus, investigated whether IL-27 may function as anti-tumor agent in human (h) PCa and analyzed the rationale for its clinical application.
|
24681516 |
2014 |
|
Malignant neoplasm of prostate
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We applied the IL-27 gene delivery protocol in vivo utilizing sonoporation (sonodelivery) with the goal of treating and reducing the growth of prostate cancer at a bone metastatic site in vivo.
|
24028178 |
2013 |
|
Malignant neoplasm of prostate
|
0.370 |
Biomarker
|
disease |
BEFREE |
We have explored the potential of a novel cytokine, interleukin-27 (IL-27), for inhibiting this malignant crosstalk, and have examined the effect of autocrine IL-27 on prostate cancer cell gene expression, as well as the effect of paracrine IL-27 on gene expression in bone and T cells.
|
23086758 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.340 |
Biomarker
|
disease |
BEFREE |
The microarray data provided evidence that viral infection, and IL-27 and IL-9 cytokine signalling contributed to the onset of T1D in two of the quadruplets.
|
22108602 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our study reveals that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
|
31801074 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Most remarkably, we identify a common missense variant in IL27, associated with type 1 diabetes that results in decreased functional activity of the protein and reduced expression levels of downstream IRF1 and STAT1 in CD4+ T cells only.
|
28248954 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.340 |
Biomarker
|
disease |
BEFREE |
IL-27 blockage delays the onset of diabetes in non obese diabetes mouse, but its role in type 1 diabetes (T1D) in human has not been reported yet.
|
23294976 |
2013 |
|
Prostatic Neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Our results suggest that IL-27 can be effective in reducing tumor growth and can help enhance accumulation of effector cells in prostate tumors in vivo.
|
21801027 |
2011 |
|
Prostatic Neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
These results are promising, because they are relevant to developing a novel IL-27-based strategy that can treat both the tumor and the bone, by using this simple and effective sonodelivery method for treating prostate tumor bone metastases.
|
24028178 |
2013 |
|
Prostatic Neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Overall, our results suggest that IL-27 may be able to modify interactions between prostate tumor and bone microenvironment cells and thus could be used as a multifunctional therapeutic for restoring bone homeostasis while treating metastatic prostate tumors.
|
23086758 |
2013 |
|
Ulcerative Colitis
|
0.170 |
AlteredExpression
|
disease |
BEFREE |
In both CD and UC, interleukin (IL)-12 (p40), IL-18, IL-21 and IL-27 transcript levels were higher than in Control.
|
28533995 |
2017 |
|
Ulcerative Colitis
|
0.170 |
Biomarker
|
disease |
BEFREE |
The IL-27 was significantly elevated in active UC and CD patients, and it was associated with disease severity.
|
27221243 |
2016 |
|
Ulcerative Colitis
|
0.170 |
Biomarker
|
disease |
BEFREE |
IL-1beta, IL-6, IL-12, and IL-27 were higher in affected areas compared to unaffected ones in UC but not CD.
|
19657406 |
2009 |
|
Ulcerative Colitis
|
0.170 |
Biomarker
|
disease |
BEFREE |
IL-27 transcripts are significantly elevated in active Crohn's disease (CD) but not in ulcerative colitis (UC).
|
19686419 |
2009 |
|
Ulcerative Colitis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrated that the genetic variant rs153109 in the 5' upstream region of IL-27 is significantly associated with UC in Chinese Han individuals.
|
28069403 |
2017 |
|
Ulcerative Colitis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Disease type-stratified subgroup analysis yielded increased risk of related diseases in IL-27 rs181206 T>C carriers in the allele model in immune thrombocytopenia (ITP), asthma, and esophageal cancer (EC) subgroups (ITP: OR=0.69, 95%CI=0.53~0.88, P=0.004; asthma: OR=0.60, 95%CI=0.41~0.89, P=0.010; EC: OR=0.79, 95%CI=0.64~0.97, P=0.026); and IL-27 rs153109 A>G polymorphism was remarkably associated with the increased risk of related diseases in the allele model in ovarian cancer (OC), systemic lupus erythematosus (SLE), tuberculosis (TB), ulcerative colitis (UC), and chronic obstructive pulmonary disease (COPD) subgroups (all P<0.05).
|
26950245 |
2016 |
|
Ulcerative Colitis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to evaluate the association between IL-27 gene polymorphisms and the development of UC.
|
26905929 |
2016 |
|
Crohn Disease
|
0.170 |
Biomarker
|
disease |
BEFREE |
Comprehensive epistasis analyses for the known CD susceptibility genes NOD2, IL23R and IL27 were performed.
|
24223725 |
2013 |
|
Crohn Disease
|
0.170 |
AlteredExpression
|
disease |
BEFREE |
Notably, increased expression of IL-23 and IL-27 transcripts in CD suggests a T helper 1-dominated immunologic function in this disease.
|
15674109 |
2005 |
|
Crohn Disease
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
We identified a significant enrichment of methylation changes within 50 kb of CD GWAS loci (8.6-fold [P = 0.021] in adults; 2.4-fold [P = 0.009] in adults and children combined), including IL-27, IL-19, TNF, MST1, and NOD2.
|
22021194 |
2012 |
|
Crohn Disease
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population.
|
25674271 |
2014 |