|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our B-ALL fluorescence in situ hybridization (FISH) panel confirmed the BCR/ABL1 fusion and monosomies consistent with chromosome studies in approximately 95% of interphase nuclei.
|
30790375 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We report on a 72-year-old male patient with a BCR/ABL1 rearrangement positive acute lymphoblastic leukemia (common ALL, or c-ALL; FAB L2 morphology) and with additional structural and numeric aberrations.
|
15721638 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.
|
11861307 |
2002 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.
|
19770381 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology.
|
19095773 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The t(9;22) BCR/ABL fusion is associated with over 90% of chronic myelogenous and 25% of acute lymphocytic leukemia.
|
16572268 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(9;22) or Philadelphia chromosome (Ph)/BCR-ABL rearrangement positive acute lymphoblastic leukemia (Ph/BCR+ ALL) is associated with a very short survival of about one year in most patients.
|
10500826 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This results in an 8.7-kilobase mRNA that encodes the P210 BCR-ABL gene product commonly found in patients with chronic myelogenous leukemia or a 7.0-kilobase mRNA that produces the P185 BCR-ABL gene product found in most Philadelphia chromosome-positive patients with acute lymphocytic leukemia.
|
2747638 |
1989 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The breakpoint on chromosome 9 is mostly 5' to ABL1 exon 2, whereas on chromosome 22, the breakpoint can occur in various regions involving the major breakpoint cluster region (M-bcr) in CML and the minor breakpoint cluster region (m-bcr) in acute lymphoblastic leukemia.
|
20633771 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Compared to CD45-low patients, CD45-high patients had a lower event-free survival rate (B-cell-precursor acute lymphoblastic leukemia: 72 ± 3% versus 86 ± 1%, P<0.0001; T-cell acute lymphoblastic leukemia: 60 ± 8% versus 78 ± 4%, P=0.02), which was mainly attributable to a higher cumulative relapse incidence (B-cell-precursor acute lymphoblastic leukemia: 22 ± 3% versus 11 ± 1%, P<0.0001; T-cell acute lymphoblastic leukemia: 31 ± 8% versus 11 ± 3%, P=0.003) and kept its significance in multivariate analysis considering sex, age, initial white blood cell count, and minimal residual disease in B-cell-precursor- and T-cell acute lymphoblastic leukemia, and additionally presence of ETV6/RUNX1, MLL/AF4 and BCR/ABL1 rearrangements in B-cell-precursor acute lymphoblastic leukemia (P=0.002 and P=0.025, respectively).
|
23911702 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additional chromosome abnormalities (ACAs), mutations of the BCR-ABL tyrosine kinase domain (TKD) and BCR-ABL splice variants may cause resistance to first- and second-generation tyrosine kinase inhibitors (TKIs) in chronic myelogenous leukemia (CML) and Philadelphia-positive (Ph+) acute lymphoid leukemia (ALL).
|
22005133 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Detection and clinical relevance of BCR-ABL fusion gene in childhood T-lineage acute lymphoblastic leukemia: a report on 4 cases.
|
19816207 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.
|
11287973 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
|
26321221 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recurrent genetic abnormalities in B-lymphoblastic leukemia with prognostic significance are well known and specifically delineated in the WHO 2008 classification (eg hyperdiploidy, t(9;22)(q34;q11.2); BCR-ABL1, t(12;21)(p13;q22); ETV6-RUNX1).
|
21822204 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Complex chromosome 9, 20, and 22 rearrangements in acute lymphoblastic leukemia with duplication of BCR and ABL sequences.
|
10640143 |
2000 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
9q34 rearrangements in BCR/ABL fusion-negative acute lymphoblastic leukemia.
|
16157197 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics.
|
15789066 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated this possibility by studying peripheral blood leukocytes from normal individuals and various hematopoietic cell lines for the presence and expression of the p210 and the p190 types of the BCR-ABL gene associated with chronic myeloid leukemia (CML) and acute lymphoblastic leukemia.
|
9787174 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis.
|
11861265 |
2002 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The BCR-ABL T315I kinase domain mutation is insensitive to dasatinib therapy for Philadelphia-positive acute lymphoid leukemia (Ph + ALL) patients.
|
22587422 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Amplification of BCR-ABL rearrangement in atypical Philadelphia chromosome: a new variant detected by fluorescence in situ hybridization in one case of acute lymphoblastic leukemia.
|
9973946 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like).
|
30401948 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Examples include the use of allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia with the BCR-ABL fusion gene or MLL rearrangement, and for acute myeloid leukemia with monosomy 7; antimetabolite-based therapy for acute lymphoblastic leukemia cases with hyperdiploidy of more than 50 chromosomes (DNA index > or = 1.16); and retinoic acid and anthracycline-containing regimens for the acute promyelocytic acute myeloid leukemia subtype with PML-RARA fusion.
|
9372085 |
1996 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia.
|
30675008 |
2019 |