|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our B-ALL fluorescence in situ hybridization (FISH) panel confirmed the BCR/ABL1 fusion and monosomies consistent with chromosome studies in approximately 95% of interphase nuclei.
|
30790375 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia.
|
30675008 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A variant transcript, e1a3, of the minor BCR-ABL fusion gene in acute lymphoblastic leukemia: case report and review of the literature.
|
18253707 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We report on a 72-year-old male patient with a BCR/ABL1 rearrangement positive acute lymphoblastic leukemia (common ALL, or c-ALL; FAB L2 morphology) and with additional structural and numeric aberrations.
|
15721638 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.
|
11861307 |
2002 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report.
|
19770381 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen.
|
24444868 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients.
|
19759560 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology.
|
19095773 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
IKZF1 deletions were associated with B-cell precursor acute lymphoblastic leukemia (P=0.036), BCR-ABL1-positive acute lymphoblastic leukemia (P<0.001), and higher white blood cell counts (P=0.005).
|
25261097 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sixty-six patients with CML in myeloid blast crisis (n = 33), lymphoid blast crisis (n = 2), accelerated phase (n = 16), chronic phase (n = 13), and BCR-ABL-positive acute lymphoblastic leukemia (n = 2) resistant to imatinib were investigated.
|
12399961 |
2002 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.
|
24997151 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The t(9;22) BCR/ABL fusion is associated with over 90% of chronic myelogenous and 25% of acute lymphocytic leukemia.
|
16572268 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We performed a comprehensive analysis of the impact of IKZF1(del) in a large cohort of children (n=1223) with BCR-ABL1-negative BCP-ALL treated in the EORTC-CLG trial 58951.
|
26050650 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A Cryptic NUP214-ABL1 Fusion in B-cell Precursor Acute Lymphoblastic Leukemia.
|
29219890 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(9;22) or Philadelphia chromosome (Ph)/BCR-ABL rearrangement positive acute lymphoblastic leukemia (Ph/BCR+ ALL) is associated with a very short survival of about one year in most patients.
|
10500826 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
IKZF1 and CRLF2 gene alterations correlate with poor prognosis in Japanese BCR-ABL1-negative high-risk B-cell precursor acute lymphoblastic leukemia.
|
23804397 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This results in an 8.7-kilobase mRNA that encodes the P210 BCR-ABL gene product commonly found in patients with chronic myelogenous leukemia or a 7.0-kilobase mRNA that produces the P185 BCR-ABL gene product found in most Philadelphia chromosome-positive patients with acute lymphocytic leukemia.
|
2747638 |
1989 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia.
|
15315963 |
2004 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Detection of BCR-ABL transcripts in acute lymphoblastic leukemia in Indian patients.
|
9585083 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
|
28579617 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The breakpoint on chromosome 9 is mostly 5' to ABL1 exon 2, whereas on chromosome 22, the breakpoint can occur in various regions involving the major breakpoint cluster region (M-bcr) in CML and the minor breakpoint cluster region (m-bcr) in acute lymphoblastic leukemia.
|
20633771 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast, recent observations in human BCR-ABL1(+) pre-B lymphoblastic leukemia cells demonstrate that Btk is constitutively phosphorylated and activated by the BCR-ABL1 fusion protein.
|
16300960 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Major BCR-ABL translocation is much more common in chronic myelogenous leukemia (CML) and minor BCR-ABL in acute lymphoblastic leukemia.
|
18722880 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Compared to CD45-low patients, CD45-high patients had a lower event-free survival rate (B-cell-precursor acute lymphoblastic leukemia: 72 ± 3% versus 86 ± 1%, P<0.0001; T-cell acute lymphoblastic leukemia: 60 ± 8% versus 78 ± 4%, P=0.02), which was mainly attributable to a higher cumulative relapse incidence (B-cell-precursor acute lymphoblastic leukemia: 22 ± 3% versus 11 ± 1%, P<0.0001; T-cell acute lymphoblastic leukemia: 31 ± 8% versus 11 ± 3%, P=0.003) and kept its significance in multivariate analysis considering sex, age, initial white blood cell count, and minimal residual disease in B-cell-precursor- and T-cell acute lymphoblastic leukemia, and additionally presence of ETV6/RUNX1, MLL/AF4 and BCR/ABL1 rearrangements in B-cell-precursor acute lymphoblastic leukemia (P=0.002 and P=0.025, respectively).
|
23911702 |
2014 |