|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ABL oncogene is consistently rearranged and activated as a consequence of the translocation t(9;22) that gives rise to the Philadelphia chromosome in chronic myeloid leukemia and in some cases of acute lymphoblastic leukemia.
|
2334939 |
1990 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This results in an 8.7-kilobase mRNA that encodes the P210 BCR-ABL gene product commonly found in patients with chronic myelogenous leukemia or a 7.0-kilobase mRNA that produces the P185 BCR-ABL gene product found in most Philadelphia chromosome-positive patients with acute lymphocytic leukemia.
|
2747638 |
1989 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, the order of loci on chromosome 22 is centromere----BCR2, BCR4, and IGL----BCR1----BCR3----SIS, possibly eliminating BCR2 and BCR4 loci as candidate targets for juxtaposition to the ABL gene in the acute lymphoblastic leukemia Ph1 chromosome.
|
3118359 |
1987 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fusion of the bcr and the c-abl genes in Ph'-positive acute lymphocytic leukemia with no rearrangement in the breakpoint cluster region.
|
3283653 |
1988 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of ABL on the Philadelphia chromosome in acute lymphoblastic leukemia is only now beginning to be understood, but is likely to be similar, and a new ABL species has already been identified by several groups.
|
3289649 |
1988 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In contrast, all BCR/ABL+ CML and acute lymphoblastic leukemia patient samples examined showed clear tyrosine-phosphorylation of CRKL.
|
7521685 |
1994 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A late-appearing Philadelphia chromosome in acute lymphoblastic leukemia confirmed by expression of BCR-ABL mRNA.
|
7564511 |
1995 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Alternative chimeric proteins, p210BCR-ABL and p190BCR-ABL, are produced that are characteristic of chronic myelogenous leukemia and acute lymphoblastic leukemia, respectively.
|
7777499 |
1995 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization.
|
8142658 |
1994 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Purging of peripheral blood stem cells yields BCR-ABL-negative autografts in patients with BCR-ABL-positive acute lymphoblastic leukemia.
|
8542955 |
1995 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical features and outcome of children with first marrow relapse of acute lymphoblastic leukemia expressing BCR-ABL fusion transcripts. BFM Relapse Study Group.
|
8608244 |
1996 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Examples include the use of allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia with the BCR-ABL fusion gene or MLL rearrangement, and for acute myeloid leukemia with monosomy 7; antimetabolite-based therapy for acute lymphoblastic leukemia cases with hyperdiploidy of more than 50 chromosomes (DNA index > or = 1.16); and retinoic acid and anthracycline-containing regimens for the acute promyelocytic acute myeloid leukemia subtype with PML-RARA fusion.
|
9372085 |
1996 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Detection of BCR-ABL transcripts in acute lymphoblastic leukemia in Indian patients.
|
9585083 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
FISH studies using Vysis LSI bcr/abl probe in interphase cells demonstrated a BCR/ABL fusion pattern, similar to that of m-BCR/ABL fusion found in acute lymphoblastic leukemia.
|
9648560 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated this possibility by studying peripheral blood leukocytes from normal individuals and various hematopoietic cell lines for the presence and expression of the p210 and the p190 types of the BCR-ABL gene associated with chronic myeloid leukemia (CML) and acute lymphoblastic leukemia.
|
9787174 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Amplification of BCR-ABL rearrangement in atypical Philadelphia chromosome: a new variant detected by fluorescence in situ hybridization in one case of acute lymphoblastic leukemia.
|
9973946 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have examined differences in the engraftment patterns in SCID mice of primary human leukemic cells isolated from children (< 21 years old) with either t(1;19)+/E2A-PBX1+ or t(9;22)+/BCR-ABL+ acute lymphoblastic leukemia.
|
10037003 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Using the reverse transcription polymerase chain reaction, we investigated acute lymphoid leukemia (ALL)-type, and chronic myelogenous leukemia (CML)-type BCR/ABL mRNA expression in a total of 66 patients with chronic myeloproliferative disorder (CMPD).
|
10374861 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
p190 BCR-ABL rearrangement in chronic myeloid leukemia and acute lymphoblastic leukemia.
|
10459357 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(9;22) or Philadelphia chromosome (Ph)/BCR-ABL rearrangement positive acute lymphoblastic leukemia (Ph/BCR+ ALL) is associated with a very short survival of about one year in most patients.
|
10500826 |
1999 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Complex chromosome 9, 20, and 22 rearrangements in acute lymphoblastic leukemia with duplication of BCR and ABL sequences.
|
10640143 |
2000 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction.
|
10654022 |
2000 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.
|
11287973 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
BCR/ABL fluorescent in situ hybridization study of chronic myeloid leukemia (CML) and Philadelphia(+) (Ph(+)) acute lymphoid leukemia (ALL) indicated that approximately 9% of patients exhibited an atypical hybridization pattern consistent with a submicroscopic deletion of the 5' region of ABL and the 3' region of the BCR genes on the 9q(+) chromosome.
|
11369654 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
BCR-ABL rearrangement frequencies in chronic myeloid leukemia and acute lymphoblastic leukemia in Ecuador, South America.
|
11801312 |
2002 |