Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The FUS gene at 16p11 fuses with DDIT3 and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the result of a t(16;21)(p11;q22) in acute myeloid leukemia.
|
12915480 |
2003 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe here a case of myxoid liposarcoma containing two novel FUS/CHOP chimeric transcripts and with the breakpoint occurring in intron 14 of FUS.
|
11162437 |
2000 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human myxoid liposarcoma contains a characteristic t(12;16) chromosomal translocation that results in fusion of the N-terminal domain of the translocated in liposarcoma (TLS) protein to the C/EBP homologous protein (CHOP).
|
12168660 |
2002 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid/round-cell liposarcoma (MLS/RCLS) is characterized by either the fusion gene FUS-DDIT3 or the less commonly occurring EWSR1-DDIT3 and most cases carry few or no additional cytogenetic changes.
|
25393000 |
2014 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components.
|
18091394 |
2007 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phase II study of amrubicin (SM-5887), a synthetic 9-aminoanthracycline, as first line treatment in patients with metastatic or unresectable soft tissue sarcoma: durable response in myxoid liposarcoma with TLS-CHOP translocation.
|
26897615 |
2016 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The FUS gene is rearranged in the t(12;16)(q13;p11) that characterizes myxoid liposarcoma and in acute myeloid leukemia with t(16;21)(p11;q22), while the ATF-1 gene is rearranged in the t(12;22)(q13;q12) found recurrently in clear cell sarcomas (malignant melanoma of soft parts).
|
11063792 |
2000 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation.
|
27270875 |
2016 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization.
|
25851712 |
2015 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respectively of type I, II and III.
|
24213580 |
2014 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report here two cases of myxoid liposarcoma containing unusual pleomorphic cells harboring FUS gene rearrangements.
|
27515548 |
2016 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
|
18850010 |
2009 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DOL54 gene [also known as megakaryocyte stimulating factor, articular superficial zone protein (SZP) or proteoglycan 4 (PRG4)], was cloned as a downstream target gene of the FUS-DDIT3 chimera, which is the fusion gene that characterizes myxoid liposarcoma (MLS).
|
15201968 |
2004 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.
|
18551309 |
2008 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS-CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.
|
15720420 |
2005 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, interphase FISH using DDIT3 and FUS probes identifies the characteristic translocation in myxoid liposarcoma.
|
18162764 |
2008 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay.
|
20581806 |
2010 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS in 22q12 has a very high homology with FUS (also called TLS) in 16p11; the latter gene is rearranged in the t(12;16)(q13;p11) that characterizes myxoid liposarcoma.
|
7533529 |
1994 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These include MDM2 and CDK4 amplification in well-differentiated and dedifferentiated liposarcomas as well as FUS-DDIT3 rearrangements in myxoid liposarcoma.
|
30793229 |
2019 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report here a very rare case of myxoid/round cell liposarcoma of the paratesticular region with type 3 DDIT3-FUS fusion gene.
|
23276404 |
2013 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.
|
12930346 |
2003 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downstream of the gene for the liposarcoma-associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M-LPS/RC-LPS) oncogene, TLS/FUS-CHOP.
|
12366807 |
2002 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, endogenous mesenchymal stem cells (MSCs) expressing TLS:CHOP developed into MRCLS in vivo.
|
22293175 |
2012 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the total number of patients is still limited, further studies are required to verify a putative association of type I FUS/DDIT3-fusion transcripts with a prognosis of MRCL.
|
17647282 |
2007 |
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
|
7566973 |
1995 |