|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blocking of this pathway by TLS-CHOP may play a mechanistic role in the establishment of myxoid liposarcoma.
|
8125258 |
1994 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
EWS in 22q12 has a very high homology with FUS (also called TLS) in 16p11; the latter gene is rearranged in the t(12;16)(q13;p11) that characterizes myxoid liposarcoma.
|
7533529 |
1994 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
|
7566973 |
1995 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe here a case of myxoid liposarcoma containing two novel FUS/CHOP chimeric transcripts and with the breakpoint occurring in intron 14 of FUS.
|
11162437 |
2000 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The FUS gene is rearranged in the t(12;16)(q13;p11) that characterizes myxoid liposarcoma and in acute myeloid leukemia with t(16;21)(p11;q22), while the ATF-1 gene is rearranged in the t(12;22)(q13;q12) found recurrently in clear cell sarcomas (malignant melanoma of soft parts).
|
11063792 |
2000 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TLS-CHOP fusion is highly sensitive and specific for the entity of classic myxoid/round cell LS.
|
11229517 |
2000 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The detection of fusion genes induced by tumor-specific translocations, such as EWS-FLI1 in Ewing's sarcoma, SYT-SSX in synovial sarcoma, and CHOP-FUS in myxoid liposarcoma, is becoming significant for clinical diagnosis, because these sarcomas are often indistinguishable from other bone and soft-tissue tumors.
|
10982695 |
2000 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downstream of the gene for the liposarcoma-associated fusion oncoprotein 54 (DOL54) is a target gene of the myxoid liposarcoma and round cell liposarcoma (M-LPS/RC-LPS) oncogene, TLS/FUS-CHOP.
|
12366807 |
2002 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human myxoid liposarcoma contains a characteristic t(12;16) chromosomal translocation that results in fusion of the N-terminal domain of the translocated in liposarcoma (TLS) protein to the C/EBP homologous protein (CHOP).
|
12168660 |
2002 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies.
|
11802205 |
2002 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The FUS gene at 16p11 fuses with DDIT3 and ATF1 as the result of translocations with chromosome band 12q13 in myxoid liposarcoma and angiomatoid fibrous histiocytoma, respectively, and with ERG as the result of a t(16;21)(p11;q22) in acute myeloid leukemia.
|
12915480 |
2003 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.
|
12930346 |
2003 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DOL54 gene [also known as megakaryocyte stimulating factor, articular superficial zone protein (SZP) or proteoglycan 4 (PRG4)], was cloned as a downstream target gene of the FUS-DDIT3 chimera, which is the fusion gene that characterizes myxoid liposarcoma (MLS).
|
15201968 |
2004 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The myxoid/round cell liposarcoma oncogene FUS-DDIT3 is the result of a translocation derived gene fusion between the splicing factor FUS and DDIT3.
|
15688424 |
2005 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS-CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.
|
15720420 |
2005 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our observations suggest that expression of FUS-CHOP may be the initiating event in myxoid liposarcoma pathogenesis, and that MPCs may constitute one cell type from which these tumors originate.
|
16849546 |
2006 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.
|
16651630 |
2006 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FUS-DDIT3 in myxoid liposarcoma) and specific oncogenic mutations (e.g.
|
16359533 |
2006 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the total number of patients is still limited, further studies are required to verify a putative association of type I FUS/DDIT3-fusion transcripts with a prognosis of MRCL.
|
17647282 |
2007 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components.
|
18091394 |
2007 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An amplification of the MDM2 and CDK4 genes respectively in the atypical lipomatous tumor/well-differentiated liposarcoma areas was detected by fluorescence in situ hybridization (FISH) analysis, and translocations of the CHOP and FUS genes were detected by FISH analysis in the myxoid/round cell liposarcoma areas.
|
18551309 |
2008 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, interphase FISH using DDIT3 and FUS probes identifies the characteristic translocation in myxoid liposarcoma.
|
18162764 |
2008 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
|
18850010 |
2009 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the case of myxoid liposarcoma (MLS) tumors, the causative abnormality is a fusion between the CHOP transcription factor and the FUS or EWS genes.
|
19190116 |
2009 |
|
Myxoid/Round Cell Liposarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay.
|
20581806 |
2010 |