|
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased lower esophageal sphincter integrated relaxation pressure (LES-IRP) is a cardinal feature of achalasia.
|
30153516 |
2019 |
|
Esophageal Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Gastro-esophageal reflux disease (GERD) may occur post-achalasia intervention due to disruption of the LES and therefore requires diligent follow-up, especially in children treated with POEM.
|
29439587 |
2018 |
|
Esophageal Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia.
|
29915812 |
2018 |
|
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia.
|
29915812 |
2018 |
|
Achalasia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Gastro-esophageal reflux disease (GERD) may occur post-achalasia intervention due to disruption of the LES and therefore requires diligent follow-up, especially in children treated with POEM.
|
29439587 |
2018 |
|
Esophagitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
HR-Manometry showed a similar reduction in the LES pressure and 4sIRP; 24-h pH-monitoring showed however an abnormal exposure to acid in 38.4% of POEM patients, as compared to 17.1% of LHD patients (p < 0.01) and esophagitis was found in 37.4% of the POEM and 15.2% of LHD patients (p < 0.05).
|
31848870 |
2020 |
|
Esophagitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The A factor (the degree of hiatal hernia), P factor (the degree of esophagitis), and pH < 4 holding time significantly improved after surgery compared with prior to surgery (p < 0.001 for all), while the LES lengths and abdominal LES lengths were extended (p < 0.001 for each).
|
30225741 |
2018 |
|
Cystic Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Nevertheless, highest resistance was documented for the nonmutator CF epidemic strain LES-1 (ST-146) detected for the first time in Spain.
|
23951065 |
2013 |
|
Cystic Fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the genes encoding ABO blood type, secretor or Lewis genotypes were not shown to associate with severity of CF lung disease, or age of onset of P. aeruginosa infection, nor was there any association with other clinical phenotypes in a group of 808 patients homozygous for the DeltaF508 mutation.
|
19169360 |
2009 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The strong correlation between the promoter activity of the FUT III gene and the high expression of sialyl Le(a) observed in different colon carcinoma cell lines seem to confirm the important regulatory role of FUT3 in the synthesis of sialyl Le(a).
|
16199102 |
2005 |
|
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
|
8909999 |
1996 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, LES-LAPG may be advantageous for anemia prevention and nutritional status improvement compared to LAPG-DTA.
|
30591490 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that serum OPN levels were strongly associated with subclinical atherosclerosis in patients with LES and it might be a useful CV biomarker that requires additional validation in larger trials.
|
30767212 |
2019 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that serum OPN levels were strongly associated with subclinical atherosclerosis in patients with LES and it might be a useful CV biomarker that requires additional validation in larger trials.
|
30767212 |
2019 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, after controlling for depression severity, significant differences between Q-LES-Q and Zung-SAS scores disappeared in MDD and BP.
|
30292023 |
2019 |
|
Deglutition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Longer myotomy on the gastric side (>2.5 cm) ensures complete division of the LES with better outcomes in term of resolution of dysphagia but may be associated with higher postoperative GERD.
|
31012870 |
2019 |
|
Toxoplasmosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
FUT3 and FUT2 genotyping and glycoconjugate profile Lewis<sup>b</sup> as a protective factor to Toxoplasma gondii infection.
|
30831115 |
2019 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
E-selectin binding activity mediated by the α1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis.
|
30988423 |
2019 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, mRNA levels of fucosyltransferase 3 (FUT3) and 6 (FUT6) were found to be high in the TRAIL-sensitive colon adenocarcinoma cell line COLO 205.
|
30589515 |
2019 |
|
Secondary malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpressed N-fucosylation on the cell surface driven by FUT3, 5, and 6 promotes cell motilities in metastatic pancreatic cancer cell lines.
|
30808544 |
2019 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, after controlling for depression severity, significant differences between Q-LES-Q and Zung-SAS scores disappeared in MDD and BP.
|
30292023 |
2019 |
|
Mammary Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A luciferase reporter assay was performed using two breast tumor cell lines to evaluate respectively the impact of FUT3 rs2306969 (-6951 CC) and (-6951 TT) on protein expression.
|
30929162 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among patients with FUT3 alleles that encode a functional protein, levels of CA19-9 above the SNP-determined cutoff values identified 66.4% of patients with PDAC, with 99.3% specificity.
|
31676359 |
2019 |
|
GASTRIC CANCER, INTESTINAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Tumor-associated FUT3 promoter polymorphism rs2306969 (-6951 C> T, position related to the gene's translation start site) has been linked to breast, ovarian and intestinal gastric cancer.
|
30929162 |
2019 |
|
Heartburn
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
There was a prevalence of acid reflux at both sphincters (p<0.0001); liquid reflux was prevalent at the LES (p=0.003) and mixed reflux at the UES (p=0.0001).
|
29307652 |
2018 |