Lupus Erythematosus, Systemic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified 10 common marker genes associated with SLE (IFI6, IFI27, IFI44L, OAS1, OAS2, EIF2AK2, PLSCR1, STAT1, RNASE2, and GSTO1).
|
27257790 |
2016 |
Lupus Erythematosus, Systemic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Lupus Vulgaris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Lupus Erythematosus, Discoid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Lupus Erythematosus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Involutional Depression
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Influenza
|
0.300 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
Major Depressive Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Involutional paraphrenia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Psychosis, Involutional
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Miscarriage
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Notably, IFI6 has little effect on other mammalian RNA viruses, including the related Flaviviridae family member hepatitis C virus, which replicates in double-membrane vesicles that protrude outwards from the ER.
|
30224801 |
2018 |
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Conclusion: A lncRNA, lncRNA-IFI6, regulates antiviral innate immunity in the JFH1 HCV infection model. lncRNA-IFI6 regulates HCV infection independently of the JAK-STAT pathway. lncRNA-IFI6 exerts its regulatory function via promoter activation and histone modification of IFI6 through its spatial domain.
|
30199576 |
2019 |
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, the results from our study support a model where IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions.
|
25757571 |
2015 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, interrupting mitochondrial functions of G1P3 may improve clinical outcomes in breast cancer patients.
|
29899394 |
2018 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer.
|
15647832 |
2005 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer.
|
20939681 |
2011 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Curtailing G1P3-mediated antiapoptotic signals could improve therapies for myeloma or other malignancies.
|
17823654 |
2007 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer.
|
15647832 |
2005 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, interrupting mitochondrial functions of G1P3 may improve clinical outcomes in breast cancer patients.
|
29899394 |
2018 |
Dengue Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we confirmed that IFI6 was markedly induced in DENV infection of both primary HUVECs and EA.hy926 cell lines.
|
26244642 |
2015 |
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Curtailing G1P3-mediated antiapoptotic signals could improve therapies for myeloma or other malignancies.
|
17823654 |
2007 |