Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer.
|
15647832 |
2005 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further analysis by EST vNorthern and virtual microarray analysis reduced the candidate genes to six, with four down-regulated genes, ANXA1, CAV1, KRT5 and MMP7, and two up-regulated genes, ERBB2 and G1P3 in breast cancer.
|
15647832 |
2005 |
Lupus Erythematosus, Systemic
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
|
16143398 |
2006 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Curtailing G1P3-mediated antiapoptotic signals could improve therapies for myeloma or other malignancies.
|
17823654 |
2007 |
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Curtailing G1P3-mediated antiapoptotic signals could improve therapies for myeloma or other malignancies.
|
17823654 |
2007 |
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Miscarriage
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that the deregulation of the PRINS ncRNA may contribute to psoriasis and results in decreased sensitivity to spontaneous keratinocyte apoptosis via the regulation of G1P3.
|
20377629 |
2010 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer.
|
20939681 |
2011 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer.
|
20939681 |
2011 |
Influenza
|
0.300 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
Lupus Erythematosus, Systemic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Lupus Vulgaris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Lupus Erythematosus, Discoid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Lupus Erythematosus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
By assessing DNA methylation levels across over 485,000 methylation sites across the entire genome, we further demonstrate that the lupus risk variant in this locus is associated with significant DNA methylation changes, including in the HLA-DR and HLA-DQ loci, as well as interferon-related genes such as IFI6, IRF6, and BST2.
|
23428850 |
2013 |
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
TNFSF10, IFI6) had altered mRNA expression both in the course of normal aging and carcinogenesis, mainly inducing proliferation and reducing apoptosis compared to healthy adults.
|
24098334 |
2013 |
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Taken together, the results from our study support a model where IFI6 inhibits HCV entry by impairing EGFR mediated CD81/CLDN1 interactions.
|
25757571 |
2015 |
Dengue Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we confirmed that IFI6 was markedly induced in DENV infection of both primary HUVECs and EA.hy926 cell lines.
|
26244642 |
2015 |
Lupus Erythematosus, Systemic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified 10 common marker genes associated with SLE (IFI6, IFI27, IFI44L, OAS1, OAS2, EIF2AK2, PLSCR1, STAT1, RNASE2, and GSTO1).
|
27257790 |
2016 |
Involutional Depression
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Major Depressive Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Involutional paraphrenia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
Psychosis, Involutional
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |