Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease PSYGENET Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence. 24687270 2014
CUI: C0424605
Disease: Developmental delay (disorder)
Developmental delay (disorder) 		0.310 Biomarker phenotype GENOMICS_ENGLAND Amino acid uptake by the mammary gland of the lactating ewe. 678219 1978
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.310 Biomarker disease GENOMICS_ENGLAND Amino acid uptake by the mammary gland of the lactating ewe. 678219 1978
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.300 Biomarker group GENOMICS_ENGLAND Amino acid uptake by the mammary gland of the lactating ewe. 678219 1978
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. 20133874 2010
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. 20133874 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.550 Biomarker disease PSYGENET Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction. 20133874 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.550 Biomarker disease CTD_human Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction. 20133874 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease CTD_human GABA(A) receptor downregulation in brains of subjects with autism. 18821008 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease CTD_human GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. 22253714 2012
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.400 Biomarker disease CTD_human GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. 22253714 2012
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.320 Biomarker disease CTD_human GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. 22253714 2012
CUI: C3160814
Disease: Cannabis use
Cannabis use 		0.310 Biomarker disease PSYGENET Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders. 18519829 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.550 Biomarker disease PSYGENET Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. 22882391 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease PSYGENET In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. 23692184 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.700 Biomarker disease PSYGENET Linkage studies of alcoholism have implicated several chromosome regions, leading to the successful identification of susceptibility genes, including ADH4 and GABRA2 on chromosome 4. 24692236 2014
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.320 Biomarker group CTD_human Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. 18313124 2008
CUI: C0376280
Disease: Anxiety States, Neurotic
Anxiety States, Neurotic 		0.300 Biomarker disease CTD_human Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. 18313124 2008
CUI: C1279420
Disease: Anxiety neurosis (finding)
Anxiety neurosis (finding) 		0.300 Biomarker disease CTD_human Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. 18313124 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.550 Biomarker disease PSYGENET The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.550 Biomarker disease CTD_human The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		0.300 Biomarker disease CTD_human The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010
CUI: C0600241
Disease: heroin abuse
heroin abuse 		0.300 Biomarker disease CTD_human The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. 19833324 2010