Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Linkage studies of alcoholism have implicated several chromosome regions, leading to the successful identification of susceptibility genes, including ADH4 and GABRA2 on chromosome 4.
|
24692236 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25.
|
23692184 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
We used linear mixed models to examine the effects of dutasteride and alcohol on BAES and SS responses and the interaction of dutasteride with the GABRA2 alcohol dependence-associated polymorphism rs279858.
|
24557088 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Variants in GABRA2 have been associated with adult alcohol dependence as well as phenotypic precursors, including impulsiveness and externalizing behaviors.
|
24975023 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
PSYGENET |
Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence.
|
24687270 |
2014 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
CTD_human |
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
|
22253714 |
2012 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence.
|
22882391 |
2013 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
PSYGENET |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
PSYGENET |
Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction.
|
20133874 |
2010 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
CTD_human |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |
Cocaine Dependence
|
0.550 |
Biomarker
|
disease |
CTD_human |
Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction.
|
20133874 |
2010 |
Alcohol Use Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
|
22253714 |
2012 |
Alcohol abuse
|
0.320 |
Biomarker
|
disease |
CTD_human |
GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
|
22253714 |
2012 |
Cannabis Dependence
|
0.320 |
Biomarker
|
disease |
PSYGENET |
We conclude that genetic variation at or near the GABRA2 locus significantly affects vulnerability not only to AD, but to other forms of substance use including ND and CD, and that the effects may be sex dependent.
|
19672139 |
2009 |
Anxiety Disorders
|
0.320 |
Biomarker
|
group |
CTD_human |
Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates.
|
18313124 |
2008 |
Cannabis use
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders.
|
18519829 |
2008 |
Developmental delay (disorder)
|
0.310 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Amino acid uptake by the mammary gland of the lactating ewe.
|
678219 |
1978 |
Global developmental delay
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Amino acid uptake by the mammary gland of the lactating ewe.
|
678219 |
1978 |
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
|
20133874 |
2010 |
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |
Heroin Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
|
20133874 |
2010 |
heroin abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |
Heroin Smoking
|
0.300 |
Biomarker
|
disease |
CTD_human |
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
|
19833324 |
2010 |