Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for seven GABRA2 single nucleotide polymorphisms (SNPs), identified from the literature as positively associated with alcohol dependence, was performed with success rates of 90% or greater.
|
21683760 |
2011 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004).
|
20698837 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
First, we tested whether a single nucleotide polymorphism within GABRA2 gene, which encodes a subunit of the GABA(A) receptor, and that has been associated with AD, influences 'extreme' alcohol intake and second, the efficacy of three psychotherapies for alcoholism in treating extreme drinking behavior.
|
20225194 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No evidence of an association was found at the allele, genotype, haplotype, or diplotype levels between the 3'-GABRA2 polymorphisms investigated and alcoholism in 149 Italian alcoholics (98 alcohol dependents and 51 alcohol abusers) and 278 controls.
|
20102561 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Consistent with previous findings, the results do not support the association between GABRA2 SNP rs279871 and AD in adolescents.
|
19783384 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The genes encoding several GABA-A receptor subunits, including GABRA2, have been associated with alcoholism, suggesting that variations in gaba signaling contribute to risk.
|
19536785 |
2010 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.
|
18818659 |
2009 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that genetic variation at or near the GABRA2 locus significantly affects vulnerability not only to AD, but to other forms of substance use including ND and CD, and that the effects may be sex dependent.
|
19672139 |
2009 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We describe analyses aimed at characterizing the pathway of risk associated with GABRA2, a gene previously associated with adult alcohol dependence, in a community sample of children followed longitudinally from childhood through young adulthood.
|
19487630 |
2009 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The GABRA2 locus has been found to be associated with alcohol dependence in several studies, but no functional variant that can account for this association has been identified.
|
17976953 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that GABRA2--originally associated with a diagnosis of alcohol dependence in adults--also predicted the onset of symptoms among subjects in their 20s, confirmed specific hypotheses about three other predictors in the fi nal model, and suggested the utility of incorporating biological and nonbiological predictors to optimally predict young adult alcohol problems.
|
18781239 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Multiple reports have identified variation in the GABRA2 gene as contributing to the genetic susceptibility to alcohol dependence.
|
18361719 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
In summary, these results extend previous findings and provide new insights into the putative biobehavioral mechanisms that may moderate the association between the GABRA2 gene, sensitivity to the acute effects of alcohol and ultimately alcohol dependence.
|
18005236 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Several recent studies have provided strong evidence that one of these genes, GABRA2, is implicated in alcoholism in humans.
|
18440057 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis indicated that genetic elements in the GABRG1 haplotype block likely contribute to AD risk in an additive manner, whereas those in the GABRA2 haplotype block may act in a dominant manner in relation to risk of AD.
|
17507911 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to confirm and extend the role of GABRA2 haplotypes in the liability to alcohol dependence.
|
17207817 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
The GABRA2 allelic associations found in clinical case-control studies have detectable but minor effects on DSM-defined alcohol dependence in the general community.
|
18727688 |
2008 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
We find no evidence of a relationship between GABRA2 and alcohol dependence.
|
17690794 |
2007 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Previous studies demonstrated, and replicated, an association between single nucleotide polymorphisms (SNPs) within the GABRA2 gene and risk for alcohol dependence.
|
17949392 |
2007 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
(d) Examination of family-based samples has identified several genes including GABRA2 and CHRM2 thought to be associated with alcohol dependence.
|
16612210 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A consistent elevation in risk for alcohol dependence associated with GABRA2 is not evident until the mid-20s and then remains throughout adulthood.
|
16557364 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have now replicated the GABRA2 association with alcoholism in 331 Plains Indian men and women and 461 Finnish Caucasian men.
|
16874763 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this paper we summarize published results from linkage and association analyses of two chromosomal regions in which the use of endophenotypes has successfully led to the identification of genes associated with alcohol dependence [GABRA2 (Edenberg et al., (2004).Am.J. Hum.Genet.
|
16341909 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.
|
16622805 |
2006 |
Alcoholic Intoxication, Chronic
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although our study was limited by the number of cases being larger than the number of controls, the results confirm GABRA2 as a susceptibility gene for alcohol dependence in the German population.
|
16395124 |
2006 |