GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		0.100 GeneticVariation phenotype GWASCAT Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. 28485404 2017
CUI: C0236970
Disease: Alcohol-Induced Disorders
Alcohol-Induced Disorders 		0.100 GeneticVariation group GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
CUI: C0236664
Disease: Alcohol-Related Disorders
Alcohol-Related Disorders 		0.100 GeneticVariation group GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.100 GeneticVariation disease GWASCAT Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. 30940813 2019
CUI: C0201874
Disease: Amino acids measurement
Amino acids measurement 		0.100 GeneticVariation group GWASCAT Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. 27005778 2016
CUI: C0201874
Disease: Amino acids measurement
Amino acids measurement 		0.100 GeneticVariation group GWASCAT Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis. 27898682 2016
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		0.100 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 Biomarker disease BEFREE GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. 26433129 2016
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease GWASCAT Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. 25646370 2016
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease GWASDB Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. 21768215 2011
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease GWASDB Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2010
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease BEFREE Three SUA correlated SNPs in Caucasian population, rs780094 in GCKR, rs1183201 in SLC17A1 and rs505802 in SLC22A12 were confirmed to be associated with gout arthritis and uric acid concentrations in Han Chinese males. 26290326 2015
CUI: C0003868
Disease: Arthritis, Gouty
Arthritis, Gouty 		0.110 GeneticVariation disease GWASCAT GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. 27899376 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease BEFREE GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. 26433129 2016
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.100 GeneticVariation disease GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
CUI: C0242216
Disease: Biliary calculi
Biliary calculi 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association meta-analysis yields 20 loci associated with gallstone disease. 30504769 2018
CUI: C0242216
Disease: Biliary calculi
Biliary calculi 		0.100 GeneticVariation phenotype GWASCAT Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies. 27094239 2016
CUI: C0200641
Disease: Blood basophil count (lab test)
Blood basophil count (lab test) 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0005823
Disease: Blood Pressure
Blood Pressure 		0.100 GeneticVariation phenotype GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Defining the role of common variation in the genomic and biological architecture of adult human height. 25282103 2014
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019