GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017654
Disease: Glomerular Filtration Rate
Glomerular Filtration Rate 		0.100 GeneticVariation phenotype GWASCAT 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. 28452372 2017
CUI: C0201976
Disease: Creatinine measurement, serum (procedure)
Creatinine measurement, serum (procedure) 		0.100 GeneticVariation phenotype GWASCAT 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. 28452372 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.060 GeneticVariation disease BEFREE Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. 22553379 2012
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.500 GeneticVariation disease BEFREE GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated. 18556336 2008
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.090 GeneticVariation group LHGDN GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated. 18556336 2008
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.090 GeneticVariation group BEFREE GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated. 18556336 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease BEFREE GCKR-L446 carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a potential molecular mechanism by which these two components of the metabolic syndrome can be dissociated. 18556336 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.500 GeneticVariation disease BEFREE GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? 21114848 2010
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.500 GeneticVariation disease BEFREE GCKR mutations in Japanese families with clustered type 2 diabetes. 21236713 2011
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.500 GeneticVariation disease BEFREE GCKR variation did not predict development of type 2 diabetes. 21525158 2011
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.070 Biomarker disease BEFREE GCKR and PNPLA3 act together to convey susceptibility to fatty liver in obese youths. 22105854 2012
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.060 Biomarker disease BEFREE GCKR and PNPLA3 act together to convey susceptibility to fatty liver in obese youths. 22105854 2012
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.490 GeneticVariation phenotype BEFREE GCKR rs780094 was also associated with decreased plasma glucose, and increased triglycerides in the patient and control groups. 24785259 2014
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.200 GeneticVariation disease BEFREE GCKR rs780094 was also associated with an increased ratio of visceral to subcutaneous fat area in the patients with nonalcoholic fatty liver disease. 24785259 2014
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 Biomarker disease BEFREE GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. 26433129 2016
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease BEFREE GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. 26433129 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.090 Biomarker disease BEFREE GKRP deacetylation-mimicking mutants dissociate from glucokinase in a glucose concentration-dependent manner in obese diabetic mouse-derived hepatocytes and increase HGU and glucose tolerance in HFD-induced or db/db obese diabetic mice. 29296001 2018
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.010 GeneticVariation phenotype BEFREE Glucokinase regulatory protein (GKRP) binds to GCK, leading to enzyme inhibition and import into the nucleus at fasting. 29704611 2018
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.060 GeneticVariation phenotype BEFREE GCKR rs780094 and CDKN2A/B rs10811661 polymorphisms were moderately associated with GDM risk. 30074065 2018
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.500 Biomarker disease BEFREE GCKR was associated with protection against type 2 diabetes (T2D) in MAs, and with hypertriglyceridemia and protection against low HDL Cholesterol (HDL-C) levels in MEZs. 30176313 2018
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.490 Biomarker phenotype BEFREE GCKR was associated with protection against type 2 diabetes (T2D) in MAs, and with hypertriglyceridemia and protection against low HDL Cholesterol (HDL-C) levels in MEZs. 30176313 2018
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.140 Biomarker group BEFREE GCKR was associated with an improved eGFR (+0.49 ml/min, 95%CI:0.10-0.89, p = 0.01) and a trend towards protection from CKD (OR:0.98, 95%CI:0.95-1.01, p = 0.13). 30352097 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 GeneticVariation disease GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
CUI: C0005823
Disease: Blood Pressure
Blood Pressure 		0.100 GeneticVariation phenotype GWASCAT A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.100 GeneticVariation phenotype GWASDB A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. 21386085 2011