|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism (C825T) in the gene encoding the G protein beta3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations.
|
12109775 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T variant of the G-protein beta3 subunit (GNB3) gene has attracted renewed attention as a candidate gene for obesity, hypertension and hyperuricemia.
|
16707857 |
2006 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This unbalanced chromosome translocation leads to duplication of over 100 genes on chromosome 12, including the obesity candidate gene G protein β3 (GNB3).
|
23980137 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Hypertension, obesity and GNB 3 gene variants.
|
16487269 |
2006 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to hypertension or obesity in northern Chinese population.
|
13679998 |
2003 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity is known to be influenced by a number of genes, including the β3 subunit of G protein (GNB3), β3-adrenergic receptor (ADRB3), uncoupling protein 2 (UCP2), and peroxisome proliferator activated receptor gamma (PPARγ).
|
24827746 |
2014 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial artificial chromosome (BAC) transgenic mice that carry an extra copy of the human GNB3 risk allele.
|
29206867 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity.
|
12730030 |
2003 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The potential for a genetic marker of obesity creates opportunities for future studies in the Inuit, not just to confirm the associations, but also to examine prospectively the influence of interventions and possible relationships between GNB3 825T and longer term complications of obesity.
|
10523525 |
1999 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T polymorphism of the G-protein beta(3) subunit gene, known to be associated with obesity, is a determinant of weight gain during pregnancy.
|
12668921 |
2003 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The potential effect of variants in three catecholaminergic pathway genes (ADRB2, ADRB3, and GNB3) on obesity-related traits was investigated in an European-derived Brazilian population.
|
16493638 |
2006 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both the gene encoding the alpha subunit of G stimulatory proteins (GNAS1) and the beta3 subunit gene (GNB3) of G proteins are associated with obesity and/or hypertension.
|
15531240 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been shown to be associated with several phenotypes such as hypertension, obesity, and diabetes mellitus comprising the metabolic syndrome.
|
15033462 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the associations of two obesity-associated genes, FTO (rs9939609) and GNB3 (rs5443) single nucleotide polymorphisms (SNPs), with early pregnancy body mass index, gestational weight gain, and postpartum weight retention.
|
29469022 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T allele of the G protein beta3-subunit gene (GNB3) is a thrifty genotype associated with an increased risk for obesity.
|
19420911 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
|
25280441 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The G protein beta 3 subunit 825T allele was recently found to be associated with hypertension and obesity which makes it a sensible candidate gene for type 2 diabetes.
|
11121369 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T-allele of the gene GNB3 encoding the G protein beta3 subunit is associated with hypertension and obesity, and identifies individuals highly responsive to diuretic therapy.
|
11927836 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T allele of the GNB3 gene has been associated with essential hypertension and obesity in cross-sectional studies.
|
14557282 |
2003 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T allele of the GNB3 gene is implicated in adipose distribution, predisposing to obesity and hypertension.
|
18192837 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, the presence of obesity reveals an association between blood pressure and the GNB3 gene in White females.
|
15226674 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.
|
19687782 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T dimorphism of the gene encoding the human G protein beta3 subunit (GNB3) is associated with hypertension and obesity.
|
12624279 |
2003 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, we investigated how genetic variation in the GNB3 gene is associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, and diabetic therapies in 427 Japanese subjects with type 2 diabetes mellitus and in 368 Japanese subjects who underwent general health examinations.
|
17161225 |
2007 |