|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the associations of two obesity-associated genes, FTO (rs9939609) and GNB3 (rs5443) single nucleotide polymorphisms (SNPs), with early pregnancy body mass index, gestational weight gain, and postpartum weight retention.
|
29469022 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial artificial chromosome (BAC) transgenic mice that carry an extra copy of the human GNB3 risk allele.
|
29206867 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity is known to be influenced by a number of genes, including the β3 subunit of G protein (GNB3), β3-adrenergic receptor (ADRB3), uncoupling protein 2 (UCP2), and peroxisome proliferator activated receptor gamma (PPARγ).
|
24827746 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
|
25280441 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in Gβ3 (GNB3) are associated with many human disorders (e.g. hypertension, diabetes and obesity) but the role of GNB3 in these pathogeneses remains unclear.
|
25093805 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sensitivity analyses excluding studies violating Hardy-Weinberg expectations, considering gender-specific effects or more extreme phenotypes (e.g. obesity only) as well as a fixed-effects "pooled" analysis also did not disclose a significant influence of GNB3 haplotypes on cardiovascular phenotypes.
|
24477587 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This unbalanced chromosome translocation leads to duplication of over 100 genes on chromosome 12, including the obesity candidate gene G protein β3 (GNB3).
|
23980137 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T allele of the G protein beta3-subunit gene (GNB3) is a thrifty genotype associated with an increased risk for obesity.
|
19420911 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene.
|
19687782 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T allele of the GNB3 gene is implicated in adipose distribution, predisposing to obesity and hypertension.
|
18192837 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that C825T variant in the gene encoding the G-protein subunit beta3 (GNB3) is associated with antipsychotic-induced weight gain and obesity.
|
18793692 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, we investigated how genetic variation in the GNB3 gene is associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, and diabetic therapies in 427 Japanese subjects with type 2 diabetes mellitus and in 368 Japanese subjects who underwent general health examinations.
|
17161225 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T variant of the G-protein beta3 subunit (GNB3) gene has attracted renewed attention as a candidate gene for obesity, hypertension and hyperuricemia.
|
16707857 |
2006 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Hypertension, obesity and GNB 3 gene variants.
|
16487269 |
2006 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The potential effect of variants in three catecholaminergic pathway genes (ADRB2, ADRB3, and GNB3) on obesity-related traits was investigated in an European-derived Brazilian population.
|
16493638 |
2006 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population.
|
16141801 |
2005 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Insulin-mediated venodilation is impaired in young, healthy carriers of the 825T allele of the G-protein beta3 subunit gene (GNB3).
|
15961981 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both the gene encoding the alpha subunit of G stimulatory proteins (GNAS1) and the beta3 subunit gene (GNB3) of G proteins are associated with obesity and/or hypertension.
|
15531240 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been shown to be associated with several phenotypes such as hypertension, obesity, and diabetes mellitus comprising the metabolic syndrome.
|
15033462 |
2004 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, the presence of obesity reveals an association between blood pressure and the GNB3 gene in White females.
|
15226674 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to hypertension or obesity in northern Chinese population.
|
13679998 |
2003 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity.
|
12730030 |
2003 |