|
Seizures
|
0.410 |
GeneticVariation
|
phenotype |
BEFREE |
The affected mother had a history of hydrocephalus, developmental delay, and seizures commonly associated with DLL1 and TBP 6q27 deletions.
|
30194807 |
2018 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Delta-like1 (DLL1) is a ligand of the Notch pathway implicated in different types of cancer, including breast cancer.
|
29366964 |
2018 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
In gain-of-function and loss-of-function studies, we demonstrated that miR-130b-3p could inhibit breast carcinoma cell invasion and migration by directly targeting the Notch ligand Delta-like 1 (DLL1).
|
28163094 |
2017 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Consistent with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to ERα<sup>+</sup> luminal breast cancer, as loss of DLL1 inhibits both tumor growth and lung metastasis of luminal breast cancer.
|
30442981 |
2019 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Consistent with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to ERα<sup>+</sup> luminal breast cancer, as loss of DLL1 inhibits both tumor growth and lung metastasis of luminal breast cancer.
|
30442981 |
2019 |
|
Malignant neoplasm of breast
|
0.320 |
Biomarker
|
disease |
BEFREE |
Delta-like1 (DLL1) is a ligand of the Notch pathway implicated in different types of cancer, including breast cancer.
|
29366964 |
2018 |
|
Global developmental delay
|
0.310 |
Biomarker
|
disease |
BEFREE |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
|
Asthma
|
0.120 |
Biomarker
|
disease |
BEFREE |
To evaluate linkage between phenotypes of asthma and gene markers of high affinity IgE receptor-beta gene (D11S97), IL-4 cytokine gene cluster (IL-4R1), and T-cell receptor alpha/delta gene complex (D14S50) in Korean nuclear families.
|
11167957 |
2001 |
|
Asthma
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of protein-tyrosine phosphatase receptor-type delta gene and its association with pediatric asthma in the Taiwanese population.
|
18414509 |
2008 |
|
Microcephaly
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Mathematical modeling showed that if the timing of Dll1 expression is changed, Hes1 oscillations are severely dampened, resulting in impaired maintenance and proliferation of neural stem cells and causing microcephaly.
|
30227160 |
2019 |
|
Holoprosencephaly
|
0.110 |
Biomarker
|
disease |
BEFREE |
These various findings implicate DLL1 in early patterning of the forebrain and identify NOTCH as a new signaling pathway involved in HPE.
|
21196490 |
2011 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Theoretically, complete TCR-delta gene rearrangements should not occur in cells other than T-lymphocytes and have only been reported once previously in BCP-ALL.
|
11380394 |
2001 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymerase chain reaction (PCR) detection of clonal T-cell receptor (TCR) gamma and delta gene rearrangements is widely used in clonality assessment of lymphoid leukemias and lymphomas and for detection of minimal residual disease of acute lymphoblastic leukemia (ALL).
|
11325643 |
2001 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T cell receptor delta gene rearrangements in acute lymphoblastic leukemia.
|
2848865 |
1988 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparison of alpha beta versus gamma delta surface expression demonstrates that all CD3+ T acute lymphoblastic leukemias with a functional V delta 1-J delta 1 rearrangement express a surface gamma delta receptor and are recognized by the anti-delta monoclonal antibody delta TCS1, whereas a control CD3+ gamma delta+ leukemic case that had not undergone V delta 1 rearrangement was delta TCS1-.
|
2529925 |
1989 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearrangement and diversification of T-cell receptor delta genes in acute lymphoblastic leukemia.
|
1328776 |
1992 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Studies of WT31 and delta TCS1 antibody reactivity showed that at least 4 of 13 CD3+ T-ALL cases expressed the delta protein.
|
2523429 |
1989 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymerase chain reaction study of the stability of Ig heavy-chain and T-cell receptor delta gene rearrangements between presentation and relapse of childhood B-lineage acute lymphoblastic leukemia.
|
8118037 |
1994 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical relevance of T-cell receptor delta gene rearrangements in childhood B-precursor cell acute lymphoblastic leukaemia.
|
9375746 |
1997 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Developmental process of the T-cell receptor alpha and delta gene assembly in B-cell precursor acute lymphoblastic leukaemia.
|
1648373 |
1991 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell receptor (TCR) delta gene rearrangements are observed in more than 80% of acute lymphoblastic leukemia (ALL) patients.
|
1824678 |
1991 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To provide a sensitive and generally applicable method to detect clonal cells in acute lymphoblastic leukemias (ALL), we have designed a new strategy based on the polymerase chain reaction (PCR) amplification of the T cell receptor gamma delta gene rearrangements found in most T and B lineage ALLs.
|
2174915 |
1990 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A clonal-specific polymerase chain reaction technique to detect T-cell receptor delta gene rearrangement in acute lymphoblastic leukaemia (ALL) and non-Hodgkin's lymphoma (NHL) was evaluated.
|
8756082 |
1996 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have used the polymerase chain reaction (PCR)-heteroduplex (HD) analysis to assess and confirm the clonal expansion of T cell receptor (TCR) gamma and delta gene rearrangements in 24 T-ALL patients at diagnosis.
|
11839375 |
2002 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell receptor alpha and delta gene assembly in B-cell precursor acute lymphoblastic leukemia.
|
1493438 |
1992 |