|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Considering the importance of monocytes in the pathophysiology of sepsis, we hypothesized that this mechanism might occur also in the clinical setting and DLL1 might serve as a biomarker of life-threatening bacterial infection.
|
31396491 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that Dll1-mediated Notch1 signaling contributes to cisplatin-induced AKI.
|
30407728 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Plasma concentrations of DLL1 were strongly elevated already at sepsis onset and maintained elevated until day 7.
|
31396491 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to ERα<sup>+</sup> luminal breast cancer, as loss of DLL1 inhibits both tumor growth and lung metastasis of luminal breast cancer.
|
30442981 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Plasma concentrations of DLL1 were strongly elevated already at sepsis onset and maintained elevated until day 7.
|
31396491 |
2019 |
|
Congenital anomaly of brain
|
0.010 |
Biomarker
|
group |
BEFREE |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
|
Morphologically abnormal structure (morphologic abnormality)
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results suggest an implication of a DLL1 defect related to the Notch signaling pathway, at least in part, in the morphologic abnormality observed in these patients.
|
31275352 |
2019 |
|
Developmental delay (disorder)
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
|
Neurodevelopmental Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals with developmental delay, intellectual disability, and brain malformations have microdeletions encompassing DLL1, we hypothesized that insufficiency of DLL1 causes a human neurodevelopmental disorder.
|
31353024 |
2019 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
We studied circulating delta-like Notch ligand 1 (DLL1) and periostin (POSTN) and CAV in de novo HTx recipients (n = 70) randomized to standard or EVR-based, calcineurin inhibitor-free immunosuppression and in maintenance HTx recipients (n = 41).
|
30312541 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of OPG, PTX3, AXL, ALCAM, sCD163, CD147, CatS and DLL1 were significantly higher in patients with COPD as compared to patients with LC.
|
30005623 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Binding sites between miR-34a and delta-like protein 1 (DLL1) were identified using a luciferase reporter system, whereas mRNA and protein expression of target genes was determined by RT-PCR and immunoblot, respectively.OA model was generated via surgery.
|
30048987 |
2018 |
|
Tuberculosis, Meningeal
|
0.010 |
Biomarker
|
disease |
BEFREE |
CSF DLL1, VDBP and fetuin exhibited fair diagnostic performance for TBM diagnosis.
|
29856234 |
2018 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these data indicate that DLL1-DCs promoted Th1 cell development to alter the Th1/Th2 ratio and ameliorate Th2-mediated allergic asthma in mice.
|
29038036 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction of Notch1 and Notch3 with Notch ligands DLL1, DLL3 and DLL4 may be important in maintaining the tumor phenotype of pancreatic cancer.
|
29896227 |
2018 |
|
Erythrocytosis due to low atmospheric pressure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To explore the genetic basis of HAPC, we investigated the association between HAPC and both phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit delta gene (PIK3CD) and collagen type IV α3 chain gene (COL4A3) in Chinese Han and Tibetan populations.
|
30053909 |
2018 |
|
Iodine deficiency syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no significant difference in Dll1 protein levels between the marginal ID and control groups at any time point.
|
30121210 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
The interaction of Notch1 and Notch3 with Notch ligands DLL1, DLL3 and DLL4 may be important in maintaining the tumor phenotype of pancreatic cancer.
|
29896227 |
2018 |
|
Drug Dependence
|
0.010 |
Biomarker
|
group |
BEFREE |
Drug addiction is a novelty-seeking personality trait that is associated with the candidate genes OPRD1 (opioid delta receptors), OPRK1 (opioid kappa receptors) and PDYN (prodynorphin).
|
28656735 |
2018 |
|
IgE-mediated food allergy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we demonstrated Notch ligand Dll1 enhanced RBL-2H3 cell degranulation and cytokine production through a novel Notch/Dok-1/MAPKs pathway, suggesting Notch signaling played a key role in the effect phase of food allergy.
|
29181775 |
2018 |
|
Cardiomyopathy, Dilated
|
0.010 |
Biomarker
|
group |
BEFREE |
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy.
|
28474304 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In CRC tissue, the expression of Dll1 and Notch1 was clearly higher than that in DM-CRC.
|
28177944 |
2017 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In CRC tissue, the expression of Dll1 and Notch1 was clearly higher than that in DM-CRC.
|
28177944 |
2017 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) Notch ligands has emerged as a major regulator of GVHD pathogenesis, little is known about the timing of essential Notch signals and the cellular source of Notch ligands after allo-BMT.
|
28319044 |
2017 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
DLL1 mRNA and protein expression levels were measured in three different neuroblastoma cell lines using quantitative real-time PCR and Western Blot analysis, respectively.
|
28525978 |
2017 |