Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.310 Biomarker disease CTD_human The mRNA levels of several genes were significantly increased in autism, including excitatory amino acid transporter 1 and glutamate receptor AMPA 1, two members of the glutamate system. 11706102 2001
CUI: C0026552
Disease: Morphine Dependence
Morphine Dependence 		0.310 Biomarker disease CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0751265
Disease: Learning Disabilities
Learning Disabilities 		0.310 Biomarker disease CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior. 18430032 2008
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior. 18430032 2008
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. 18486119 2008
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. 18486119 2008
CUI: C0016722
Disease: Frigidity
Frigidity 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0020594
Disease: Hypoactive Sexual Desire Disorder
Hypoactive Sexual Desire Disorder 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0020649
Disease: Hypotension
Hypotension 		0.300 Biomarker phenotype CTD_human These results suggest that excitatory afferent signals from the peripheral vestibular receptors, resulting from acute hypotension, release glutamate into postsynaptic neurons in the vestibular nuclei and the excitatory signals are transmitted through the GluR1 subunit of the AMPA receptors and the NR2B subunits of the NMDA receptors in the vestibular system. 18639534 2008
CUI: C0023186
Disease: Learning Disorders
Learning Disorders 		0.300 Biomarker group CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007
CUI: C0029261
Disease: Orgasmic Disorder
Orgasmic Disorder 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0033953
Disease: Psychosexual Disorders
Psychosexual Disorders 		0.300 Biomarker group CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0036902
Disease: Sexual Arousal Disorder
Sexual Arousal Disorder 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003