Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036337
Disease: Schizoaffective Disorder
Schizoaffective Disorder 		0.500 Biomarker disease PSYGENET Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? 21693126 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease PSYGENET A significantly increased risk of schizophrenia was associated with the A allele of rs1428920 and rs2926835 of GRIA1. 23053966 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease PSYGENET Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder? 21693126 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.380 Biomarker disease PSYGENET Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. 24725413 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.380 Biomarker disease PSYGENET Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes. 24895223 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes. 24895223 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. 24725413 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.380 Biomarker disease PSYGENET βCaMKII in lateral habenula mediates core symptoms of depression. 23990563 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.380 Biomarker disease PSYGENET Our results provide evidence for a significant role of hippocampal GluA1-containing AMPA receptors and their PDZ-interaction in experience-dependent expression of behavioral despair and link mechanisms of hippocampal synaptic plasticity with behavioral expression of depression. 23262314 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.380 Biomarker disease PSYGENET The role of GluA1 in ocular dominance plasticity in the mouse visual cortex. 24048851 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET The role of GluA1 in ocular dominance plasticity in the mouse visual cortex. 24048851 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET Our results provide evidence for a significant role of hippocampal GluA1-containing AMPA receptors and their PDZ-interaction in experience-dependent expression of behavioral despair and link mechanisms of hippocampal synaptic plasticity with behavioral expression of depression. 23262314 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET βCaMKII in lateral habenula mediates core symptoms of depression. 23990563 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET Our results suggest that 17 SNPs within GRIA1, GRIA2 and GRIA4 may not be associated with the development and treatment outcomes in BD. 22122651 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET A combined analysis of all 60 families continued to support evidence for association of GRIA1 with psychotic BP; however, individual SNPs could not be replicated across datasets. 18484081 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET Interestingly, GRIA1 mRNA was significantly increased in both cell types in the schizophrenia group compare to controls, while similar trends were observed in major depressive disorder (Layers II/III and V) and bipolar disorder (Layer V). 17942280 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively. 17299517 2007
CUI: C0751265
Disease: Learning Disabilities
Learning Disabilities 		0.310 Biomarker disease CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.310 Biomarker disease CTD_human The mRNA levels of several genes were significantly increased in autism, including excitatory amino acid transporter 1 and glutamate receptor AMPA 1, two members of the glutamate system. 11706102 2001
CUI: C0026552
Disease: Morphine Dependence
Morphine Dependence 		0.310 Biomarker disease CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.300 Biomarker group GENOMICS_ENGLAND Genome sequencing identifies major causes of severe intellectual disability. 24896178 2014
CUI: C0016722
Disease: Frigidity
Frigidity 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0020594
Disease: Hypoactive Sexual Desire Disorder
Hypoactive Sexual Desire Disorder 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0029261
Disease: Orgasmic Disorder
Orgasmic Disorder 		0.300 Biomarker disease CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009
CUI: C0033953
Disease: Psychosexual Disorders
Psychosexual Disorders 		0.300 Biomarker group CTD_human Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. 19295509 2009