Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.310 Biomarker disease CTD_human The mRNA levels of several genes were significantly increased in autism, including excitatory amino acid transporter 1 and glutamate receptor AMPA 1, two members of the glutamate system. 11706102 2001
CUI: C0026552
Disease: Morphine Dependence
Morphine Dependence 		0.310 Biomarker disease CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0600272
Disease: Morphine Abuse
Morphine Abuse 		0.300 Biomarker disease CTD_human Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits. 11404432 2001
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0038587
Disease: Substance Withdrawal Syndrome
Substance Withdrawal Syndrome 		0.300 Biomarker disease CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003
CUI: C0086189
Disease: Drug Withdrawal Symptoms
Drug Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003
CUI: C0087169
Disease: Withdrawal Symptoms
Withdrawal Symptoms 		0.300 Biomarker phenotype CTD_human Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. 12511956 2003
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Therapeutic group CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.300 Biomarker disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.300 Therapeutic disease CTD_human Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. 14684464 2003
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Biomarker group CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.300 Therapeutic group CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.300 Biomarker disease CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.300 Therapeutic disease CTD_human Extinction-induced neuroplasticity attenuates stress-induced cocaine seeking: a state-dependent learning hypothesis. 15764012 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET Interestingly, GRIA1 mRNA was significantly increased in both cell types in the schizophrenia group compare to controls, while similar trends were observed in major depressive disorder (Layers II/III and V) and bipolar disorder (Layer V). 17942280 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.320 Biomarker disease PSYGENET In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively. 17299517 2007
CUI: C0751265
Disease: Learning Disabilities
Learning Disabilities 		0.310 Biomarker disease CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Therapeutic disease CTD_human AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues. 16495937 2007