Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 GeneticVariation disease BEFREE We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1,642 individuals from the TwinsUK study. 29243543 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 AlteredExpression disease BEFREE These changes in glutamatergic activity reverse when Grik4 levels are normalized; thus, they may account for the behavioral abnormalities in disorders like autism or schizophrenia. 29949767 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET GluK4 knockout mice also showed marked hyperactivity and impaired pre-pulse inhibition, thereby mirroring two of the hallmark endophenotypes of patients with schizophrenia and bipolar disorder. 23357115 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease PSYGENET GluK4 knockout mice also showed marked hyperactivity and impaired pre-pulse inhibition, thereby mirroring two of the hallmark endophenotypes of patients with schizophrenia and bipolar disorder. 23357115 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET These results support our hypothesis that the deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. 22052594 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease BEFREE These results support our hypothesis that the deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. 22052594 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 GeneticVariation disease LHGDN A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. 18824690 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. 18824690 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease PSYGENET These results suggest that the five SNPs within the GRIK4 gene are unlikely to play a major role in the susceptibility to schizophrenia in the Chinese population. 18289755 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 GeneticVariation disease BEFREE These results suggest that the five SNPs within the GRIK4 gene are unlikely to play a major role in the susceptibility to schizophrenia in the Chinese population. 18289755 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET This gene is disrupted by a translocation breakpoint in a patient with schizophrenia, and case control studies show significant association of GRIK4 with both schizophrenia and bipolar disorder. 17449450 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease BEFREE This gene is disrupted by a translocation breakpoint in a patient with schizophrenia, and case control studies show significant association of GRIK4 with both schizophrenia and bipolar disorder. 17449450 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease BEFREE This gene is disrupted by a translocation breakpoint in a patient with schizophrenia, and case control studies show significant association of GRIK4 with both schizophrenia and bipolar disorder. 17449450 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease PSYGENET This gene is disrupted by a translocation breakpoint in a patient with schizophrenia, and case control studies show significant association of GRIK4 with both schizophrenia and bipolar disorder. 17449450 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease BEFREE Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. 16819533 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.350 Biomarker disease PSYGENET This identified two discrete regions of disease risk within the GRIK4 locus: three single single nucleotide polymorphism (SNP) markers with a corresponding underlying haplotype associated with susceptibility to schizophrenia (P=0.0005, odds ratio (OR) of 1.453, 95% CI 1.182-1.787) and two single SNP markers and a haplotype associated with a protective effect against bipolar disorder (P=0.0002, OR of 0.624, 95% CI 0.485-0.802). 16819533 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease PSYGENET Here we report association studies of schizophrenia with polymorphisms in three kainate receptor genes: GRIK3, GRIK4 and GRIK5. 16325263 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease LHGDN This identified two discrete regions of disease risk within the GRIK4 locus: three single single nucleotide polymorphism (SNP) markers with a corresponding underlying haplotype associated with susceptibility to schizophrenia (P=0.0005, odds ratio (OR) of 1.453, 95% CI 1.182-1.787) and two single SNP markers and a haplotype associated with a protective effect against bipolar disorder (P=0.0002, OR of 0.624, 95% CI 0.485-0.802). 16819533 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 Biomarker disease BEFREE Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia. 16325263 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.350 GeneticVariation disease BEFREE This identified two discrete regions of disease risk within the GRIK4 locus: three single single nucleotide polymorphism (SNP) markers with a corresponding underlying haplotype associated with susceptibility to schizophrenia (P=0.0005, odds ratio (OR) of 1.453, 95% CI 1.182-1.787) and two single SNP markers and a haplotype associated with a protective effect against bipolar disorder (P=0.0002, OR of 0.624, 95% CI 0.485-0.802). 16819533 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE Accumulated evidence implicates the involvement of glutamatergic receptors in the pathophysiology of MDD and antidepressant treatment.By using 193 MDD patients who have been taking venlafaxine for 6 weeks, we investigated whether single nucleotide polymorphisms (SNPs) in glutamate ionotropic receptor kainate type subunit 4 (GRIK4), glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) and glutamate metabotropic receptor 7 (GRM7) were associated with treatment response. 31083176 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE In summary, our results firstly indicated that rs56275759 of GRIK4 gene might be associated with MDD in Chinese Han population. 28583584 2017
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. 22222462 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Failure to replicate influence of GRIK4 and GNB3 polymorphisms on treatment outcome in major depression. 22222462 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 GeneticVariation disease BEFREE Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population. 28583584 2017