|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Whether dual GLP-1R/GCR agonism represents a treatment method that is superior to pure GLP-1R agonists for obesity and diabetes treatment remains to be confirmed.
|
30091218 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Several recent studies have suggested that compounds known as endocrine-disrupting chemicals (EDCs) can promote obesity by serving as ligands for nuclear receptors, including the peroxisome proliferator-activated receptor γ (PPARγ) and the glucocorticoid receptor (GR).
|
29126303 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Stress-induced GCs hyper-secretion triggers glucocorticoid receptor (GR)-dependent transcriptional factor, nuclear factor kappa B (NFκB), which interferes TNFα-IL6 and keap1-Nrf2 pathways in liver regeneration and obesity through fine-tuning of TNFα, IL6 and Nrf2 signaling.
|
29566366 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Regulators of glucocorticoid receptor function in an animal model of depression and obesity.
|
29524264 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids can bind and activate both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and pharmacological blockades of MR prevent high-fat diet-induced obesity and glucose intolerance.
|
30307154 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids can bind and activate both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and pharmacological blockades of MR prevents high-fat diet-induced obesity and glucose intolerance.
|
30049823 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Both GR and MR are deeply involved in adipogenesis and adipose expansion; hence pharmacological blockade of these two receptors has proven effective against adipose tissue dysfunction in experimental models of obesity and metabolic syndrome (MetS), suggesting a potential use for MR and GR antagonists in these clinical settings.
|
28915330 |
2017 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid receptor polymorphism in obesity and glucose homeostasis.
|
28397446 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data suggest that decreasing GR by administration of myokines may be a promising therapy for treating patients with obesity or diabetes.
|
26896766 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Particularly, miR-379 was up-regulated in mouse models of hyperglucocorticoidemia and obesity as well as human liver in a GC/GR-dependent manner.
|
25510864 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Serum cortisol concentrations fluctuate in a circadian fashion, and glucocorticoids exert strong effects on adipose tissue and induce obesity through the glucocorticoid receptor.
|
23784897 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
9 SNPs in biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) were genotyped in 1,156 unrelated Mexican-Mestizos including 683 cases (441 obese class I/II and 242 obese class III) and 473 normal-weight controls.
|
23950976 |
2013 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
As the effects of glucocorticoids are mediated by the glucocorticoid receptor, encoded by NR3C1 gene, different polymorphisms in the NR3C1 gene have been linked to altered glucocorticoid sensitivity in general population as well as in patients with obesity or metabolic syndrome.
|
22587831 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
To further characterize the tissue-specific cortisol regeneration in obesity, we have investigated the mRNA expression of genes related to local cortisol production, i.e., 11β-HSD1, hexose-6-phosphate dehydrogenase (H6PDH) and cortisol action, glucocorticoid receptor (GR) and a cortisol target gene, phosphoenolpyruvate carboxykinase (PEPCK) in the liver, and visceral (VAT) and subcutaneous (SAT) adipose tissues from morbidly obese patients with and without metabolic syndrome (MS).
|
21964795 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overall, this study provides new data showing the influence of glucocorticoid receptor and corticosteroid-binding globulin genes in obesity and/or cortisol action in prepubertal obese children.
|
22576823 |
2012 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Previous studies have found associations between single nucleotide polymorphisms in clock genes or downstream hormone receptors such as the leptin receptor (LEPR) or glucocorticoid receptor (NR3C1) and obesity in the healthy population, but this association remains to be examined in patients with schizophrenia treated with antipsychotics.
|
21050724 |
2011 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
Functional variability in corticosteroid receptors is a major component of strain differences in fat deposition and metabolic consequences of enriched diets in rat.
|
20723946 |
2011 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity.
|
20440229 |
2010 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A brief update of glucocorticoid receptor variants and obesity risk.
|
17148738 |
2006 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The glucocorticoid receptor (GR) may be a common link between human obesity/metabolic syndrome and Cushing's syndrome.
|
16855182 |
2006 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We conducted a meta-analysis to assess the association between the N363S polymorphism of the GRL gene and obesity risk.
|
16725041 |
2006 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Genetic variation in the peroxisome proliferator-activated receptor gamma2 (PPARgamma2), glucocorticoid receptor (GRL), and ciliary neurotrophic factor (CNTF) genes may play a role in the etiology of obesity.
|
16210701 |
2005 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There was an association between this GR polymorphism and both awakening salivary cortisol and postdexamethasone salivary cortisol but no association for obesity or metabolic parameters.
|
16222046 |
2005 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These data confirm that idiopathic obesity is associated with transcriptional up-regulation of 11HSD1 in adipose, which is not detected by conventional in vivo measurements of urinary cortisol metabolites and is not accompanied by dysregulation of GR.
|
12915696 |
2003 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (A1220G; N363S) in exon 2 of the glucocorticoid receptor gene (NR3C1), associated with increased sensitivity to glucocorticoids, was shown to be associated with obesity in nondiabetic subjects.
|
12864802 |
2003 |