We studied whether genetic variants, such as N363S (rs56149945), exon 9-β (rs6198), ER22/23EK (rs6189-6190), and the intronic BclI restriction site (rs41423247) polymorphisms in the GR gene, could be considered as risk factors for the development of EDs and obesity in Italian patients.
The NR3C1 N363S variant is associated with obesity and overweight in a range of patient settings but is not associated with hypertension or type 2 diabetes.
A single nucleotide polymorphism (A1220G; N363S) in exon 2 of the glucocorticoid receptor gene (NR3C1), associated with increased sensitivity to glucocorticoids, was shown to be associated with obesity in nondiabetic subjects.
Taking the results of this study and those obtained in the Dutch population, we speculate that heterozygous carriers of the N363S variant who develop obesity, may become even more obese, possibly because they have a hypersensitive insulin response and thus, via activation of lipogenesis, store fat more efficiently.
The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus.
We studied whether genetic variants, such as N363S (rs56149945), exon 9-β (rs6198), ER22/23EK (rs6189-6190), and the intronic BclI restriction site (rs41423247) polymorphisms in the GR gene, could be considered as risk factors for the development of EDs and obesity in Italian patients.
We studied whether genetic variants, such as N363S (rs56149945), exon 9-β (rs6198), ER22/23EK (rs6189-6190), and the intronic BclI restriction site (rs41423247) polymorphisms in the GR gene, could be considered as risk factors for the development of EDs and obesity in Italian patients.
We studied whether genetic variants, such as N363S (rs56149945), exon 9-β (rs6198), ER22/23EK (rs6189-6190), and the intronic BclI restriction site (rs41423247) polymorphisms in the GR gene, could be considered as risk factors for the development of EDs and obesity in Italian patients.