GRM4, glutamate metabotropic receptor 4, 2914

N. diseases: 54; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE Thus, this study did not provide evidence for the contribution of the mGluR4 gene to schizophrenia in the Japanese. 11525421 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET Thus, this study did not provide evidence for the contribution of the mGluR4 gene to schizophrenia in the Japanese. 11525421 2001
CUI: C0270853
Disease: Juvenile Myoclonic Epilepsy
Juvenile Myoclonic Epilepsy 		0.040 GeneticVariation disease BEFREE The mGluR4 gene also falls within a susceptibility locus for juvenile myoclonic epilepsy suggesting a potential link to this form of epilepsy. 11223165 2001
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.020 GeneticVariation disease BEFREE Localization of the human mGluR4 gene within an epilepsy susceptibility locus(1). 11223165 2001
CUI: C0036572
Disease: Seizures
Seizures 		0.010 GeneticVariation phenotype BEFREE Disruption of the mGluR4 gene in mice results in impaired motor and spatial learning, and alterations in seizure susceptibility. 11223165 2001
CUI: C0270853
Disease: Juvenile Myoclonic Epilepsy
Juvenile Myoclonic Epilepsy 		0.040 GeneticVariation disease BEFREE Our results provide no evidence that genetic variation of the GRM4 gene confers susceptibility to JME-related IGE syndromes. 14582146 2003
CUI: C0270850
Disease: Idiopathic generalized epilepsy
Idiopathic generalized epilepsy 		0.020 GeneticVariation disease BEFREE Our results provide no evidence that genetic variation of the GRM4 gene confers susceptibility to JME-related IGE syndromes. 14582146 2003
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.010 Biomarker group LHGDN Metabotropic glutamate receptor 4-mediated 5-Fluorouracil resistance in a human colon cancer cell line. 15217955 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET Six genes (DAO, GRM3, GRM4, GRIN2B, IL2RB, and TUBA8) met this criterion for bipolar I disorder; only DAO has been previously associated with bipolar disorder. 16380905 2005
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.300 Biomarker disease CTD_human Here, we examine the transcription levels of mGluRs class I (mGluR1 and 5) and III (mGluR4 and 7) in experimental TLE and correlate differential mGluR subunit expression with mouse-strain-dependent susceptibility to TLE induced by pilocarpine. 15694259 2005
CUI: C0014558
Disease: Uncinate Epilepsy
Uncinate Epilepsy 		0.300 Biomarker disease CTD_human Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. 15694259 2005
CUI: C0393672
Disease: Epilepsy, Benign Psychomotor, Childhood
Epilepsy, Benign Psychomotor, Childhood 		0.300 Biomarker disease CTD_human Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. 15694259 2005
CUI: C0393682
Disease: Epilepsy, Lateral Temporal
Epilepsy, Lateral Temporal 		0.300 Biomarker disease CTD_human Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. 15694259 2005
CUI: C0026269
Disease: Mitral Valve Stenosis
Mitral Valve Stenosis 		0.010 Biomarker disease BEFREE No mGluR4 IR was detected in cells of the microglia/macrophage lineage in the MS lesions studied. 15589052 2005
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.010 Biomarker disease BEFREE No mGluR4 IR was detected in cells of the microglia/macrophage lineage in the MS lesions studied. 15589052 2005
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 Biomarker disease LHGDN These data suggest that mGlu4 receptor enhancers are promising drugs for the treatment of medulloblastomas. 16899734 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET Several candidate genes for schizophrenia may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6. 17239033 2007
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.300 Therapeutic phenotype CTD_human Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. 17446080 2007
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.020 GeneticVariation disease BEFREE Presence of epilepsy, although rare in patients with 6p duplication may be linked to genes involved in brain function and synaptic transmission in the 6p21.2p22.1 duplicated region (GABBR1, BRD2 and GRM4). 18463015 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population. 19351574 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET We conclude that at least one susceptibility locus for schizophrenia is located within or nearby GRM7, whereas GRM4 is unlikely to be a major susceptibility gene for schizophrenia in the Japanese population. 19351574 2009
CUI: C0270853
Disease: Juvenile Myoclonic Epilepsy
Juvenile Myoclonic Epilepsy 		0.040 Biomarker disease BEFREE Nominally significant associations were detected between IGE and seven GRM4 SNPs (with P-values ranging from 0.037 to 0.0036), between JME and five SNPs (P=0.042-0.0106), and between CAE and two SNPs (P=0.0466-0.0021). 20338729 2010
CUI: C0270850
Disease: Idiopathic generalized epilepsy
Idiopathic generalized epilepsy 		0.020 GeneticVariation disease BEFREE Association analysis was carried out for 17 single nucleotide polymorphisms (SNPs) covering the genomic GRM4 sequence for all IGE patients as well as for two common IGE subsyndromes [Juvenile Myoclonic Epilepsy (JME, n=215) and Childhood Absence Epilepsy (CAE, n=175)]. 20338729 2010
CUI: C0014548
Disease: Epilepsy, Generalized
Epilepsy, Generalized 		0.010 Biomarker disease BEFREE Role of GRM4 in idiopathic generalized epilepsies analysed by genetic association and sequence analysis. 20338729 2010
CUI: C0014553
Disease: Absence Epilepsy
Absence Epilepsy 		0.010 GeneticVariation disease BEFREE Association analysis was carried out for 17 single nucleotide polymorphisms (SNPs) covering the genomic GRM4 sequence for all IGE patients as well as for two common IGE subsyndromes [Juvenile Myoclonic Epilepsy (JME, n=215) and Childhood Absence Epilepsy (CAE, n=175)]. 20338729 2010