GRM4, glutamate metabotropic receptor 4, 2914

N. diseases: 54; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4. 31581881 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.010 GeneticVariation disease BEFREE A genetic variant in miRNA binding site of glutamate receptor 4, metabotropic (GRM4) is associated with increased risk of major depressive disorder. 27792966 2017
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.010 GeneticVariation disease BEFREE Additional analysis has revealed a significant genotype-expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. 30488581 2018
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.010 GeneticVariation disease BEFREE Additional analysis has revealed a significant genotype-expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. 30488581 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.450 Biomarker disease BEFREE Agonists of GRM4 or a neutralizing antibody to IL23 suppressed osteosarcoma growth in mice. 31527131 2019
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.050 Biomarker disease BEFREE Agonists of GRM4 or a neutralizing antibody to IL23 suppressed osteosarcoma growth in mice. 31527131 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 Biomarker disease BEFREE Agonists of GRM4 or a neutralizing antibody to IL23 suppressed osteosarcoma growth in mice. 31527131 2019
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.450 AlteredExpression disease BEFREE Analysis of TCGA database showed that there was no substantial deviation in the expression of GRM4 between osteosarcoma and normal tissues. 31581881 2020
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.050 AlteredExpression disease BEFREE Analysis of TCGA database showed that there was no substantial deviation in the expression of GRM4 between osteosarcoma and normal tissues. 31581881 2020
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.050 AlteredExpression disease BEFREE Analysis of TCGA database showed that there was no substantial deviation in the expression of GRM4 between osteosarcoma and normal tissues. 31581881 2020
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.010 Biomarker group BEFREE Areas covered: This review gives to discussion to the past and recent advances (between 2012-2017) in targeting the mGlu4 receptor for the treatment of disorders of the central nervous system (CNS) as well as immunological (neuroinflammation) and metabolic diseases (diabetes). 29486616 2018
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.010 Biomarker phenotype BEFREE As class C GPCRs and regulators of synaptic activity, human metabotropic glutamate receptors (mGluRs) 4 and 5 are prime targets for allosteric modulation, with mGlu5 inhibition or mGlu4 stimulation potentially treating conditions like chronic pain and Parkinson's disease. 28694498 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 Biomarker disease BEFREE As class C GPCRs and regulators of synaptic activity, human metabotropic glutamate receptors (mGluRs) 4 and 5 are prime targets for allosteric modulation, with mGlu5 inhibition or mGlu4 stimulation potentially treating conditions like chronic pain and Parkinson's disease. 28694498 2017
CUI: C0270850
Disease: Idiopathic generalized epilepsy
Idiopathic generalized epilepsy 		0.020 GeneticVariation disease BEFREE Association analysis was carried out for 17 single nucleotide polymorphisms (SNPs) covering the genomic GRM4 sequence for all IGE patients as well as for two common IGE subsyndromes [Juvenile Myoclonic Epilepsy (JME, n=215) and Childhood Absence Epilepsy (CAE, n=175)]. 20338729 2010
CUI: C0014553
Disease: Absence Epilepsy
Absence Epilepsy 		0.010 GeneticVariation disease BEFREE Association analysis was carried out for 17 single nucleotide polymorphisms (SNPs) covering the genomic GRM4 sequence for all IGE patients as well as for two common IGE subsyndromes [Juvenile Myoclonic Epilepsy (JME, n=215) and Childhood Absence Epilepsy (CAE, n=175)]. 20338729 2010
CUI: C4281785
Disease: Childhood Absence Epilepsy
Childhood Absence Epilepsy 		0.010 GeneticVariation disease BEFREE Association analysis was carried out for 17 single nucleotide polymorphisms (SNPs) covering the genomic GRM4 sequence for all IGE patients as well as for two common IGE subsyndromes [Juvenile Myoclonic Epilepsy (JME, n=215) and Childhood Absence Epilepsy (CAE, n=175)]. 20338729 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET Changes in paired-pulse facilitation that became overt in the presence of the GABAA antagonist picrotoxin indicated a function of mGluR4 in maintaining the excitation/inhibition balance, which is of crucial importance for information processing in the brain and the deterioration of these processes in neuropsychological disorders such as autism, epilepsy and schizophrenia. 23714430 2013
CUI: C0036572
Disease: Seizures
Seizures 		0.010 GeneticVariation phenotype BEFREE Disruption of the mGluR4 gene in mice results in impaired motor and spatial learning, and alterations in seizure susceptibility. 11223165 2001
CUI: C0234251
Disease: Inflammatory pain
Inflammatory pain 		0.010 Biomarker phenotype BEFREE Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4. 27994221 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 AlteredExpression disease BEFREE Ectopic expression of GRM4 was correlated with better prognosis of breast cancer patients. 31492116 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE Ectopic expression of GRM4 was correlated with better prognosis of breast cancer patients. 31492116 2019
CUI: C0014558
Disease: Uncinate Epilepsy
Uncinate Epilepsy 		0.300 Biomarker disease CTD_human Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. 15694259 2005
CUI: C0393672
Disease: Epilepsy, Benign Psychomotor, Childhood
Epilepsy, Benign Psychomotor, Childhood 		0.300 Biomarker disease CTD_human Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. 15694259 2005
CUI: C0393682
Disease: Epilepsy, Lateral Temporal
Epilepsy, Lateral Temporal 		0.300 Biomarker disease CTD_human Expression analysis of metabotropic glutamate receptors I and III in mouse strains with different susceptibility to experimental temporal lobe epilepsy. 15694259 2005
CUI: C0027746
Disease: Nerve Degeneration
Nerve Degeneration 		0.300 Therapeutic phenotype CTD_human Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. 17446080 2007