|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to investigate the role of GSTT1 and GSTM1 gene polymorphisms in asthma pathogenesis in a North Indian population.
|
22484660 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
We found that asthmatic patients with two copies of GSTM1 were significantly underrepresented (p<0.0005) and the significance increased by 10-fold when only atopic asthmatics were analyzed (p<0.00005).
|
15300848 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the reduced and statistically insignificant asthma risk was observed among those with GSTM1 null genotype.
|
16162701 |
2005 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 or GSTT1 polymorphisms had also no relevant developing effect on NP patients without or with asthma.
|
16550944 |
2006 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
[Comparative analysis of polymorphisms in gene of glutathione-S-transferases in citizens of north-western part of Russia--healthy individuals and patients with bronchial asthma].
|
12325261 |
2002 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of higher CG methylation levels of <i>LMO2_E148, IL10_P325</i>, and <i>GSTM1_P266</i> corresponded to the highest risk of asthma by 43.48%, compared to other combinations (16.67-23.08%) in the 3-way multi-factor dimensionality reduction (MDR) analysis.
|
31214241 |
2019 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, among subjects with homozygous deletion of GSTM1, carriers of a serine allele were at significantly reduced risk of asthma compared with Pro/Pro homozygotes (relative risk = 0.4; 95% confidence interval, 0.2-0.8).
|
12969868 |
2003 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence.
|
27043549 |
2016 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of TNF G-308A with asthma and wheezing and to determine whether these associations vary with ozone exposure and GSTM1 and GSTP1 genotype.
|
16456144 |
2006 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Acute effects of walking environment and GSTM1 variants in children with asthma.
|
21196426 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of the GSTM1 gene (null genotype) was associated with a 1.89-fold risk of diisocyanate-induced asthma [95% confidence interval (CI) 1.01-3.52].
|
11470996 |
2001 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Importantly, polymorphisms in an oxidative stress gene (GSTM1) have predicted patients with asthma who benefit from antioxidant supplementation in Mexico City, which has chronically high ozone exposure.
|
18511640 |
2008 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the increased asthma risk associated with h0111101 was restricted to children with the GSTM1 "null" genotype (interaction p=0.002, HR 1.89, 95% CI 1.34 to 2.60).
|
19996333 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Asthma patients (63.4%) had a higher prevalence of the GSTM1 null genotype than the control group (40.8%; OR = 2.34; 95% CI, 1.31-4.20).
|
15612961 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma.
|
21325943 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In children lacking the GSTM1 allele who were exposed to current ETS the risk for current asthma (OR 5.5, 95% CI 1.6 to 18.6) and asthma symptoms such as wheeze ever (OR 2.8, 95% CI 1.3 to 6.0), current wheezing (OR 4.7, 95% CI 1.8 to 12.6) and shortness of breath (OR 8.9, 95% CI 2.1 to 38.4) was higher than in GSTM1 positive individuals without ETS exposure.
|
15223862 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma.
|
15148962 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis provides evidence that GSTM1 and GSTT1 polymorphisms may be risk factors for asthma.
|
23600494 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether common, functional polymorphisms in GSTM1, GSTP1 and NQO1 influence airway hyperreactivity (AHR) and atopy among schoolchildren in South Africa.
|
20526719 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Asthma patients (63.4%) had a higher prevalence of the GSTM1 null genotype than the control group (40.8%; OR = 2.34; 95% CI, 1.31-4.20).
|
15612961 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The NQO1 gene might be involved in the development of asthma, especially in children carrying the GSTM1 null genotype who are exposed to ETS.
|
19591959 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the role of polymorphisms in the GSTT1, GSTM1 and GSTP1 genes and asthma susceptibility in Egyptian children, and to analyze their effect on GST activity and lung function.
|
22326267 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GST1 (GSTT1) null genotypes were associated with current asthma (OR 1.43, 95% CI 1.00-2.04) and medication use (OR 1.46, 95% CI 1.01-2.22).
|
21109554 |
2011 |