Hepatitis
|
0.040 |
Biomarker
|
group |
BEFREE |
The GST1 0 phenotype was found more frequently in livers with hepatitis and carcinoma than in control livers.
|
3570286 |
1987 |
Hepatitis A
|
0.030 |
Biomarker
|
disease |
BEFREE |
The GST1 0 phenotype was found more frequently in livers with hepatitis and carcinoma than in control livers.
|
3570286 |
1987 |
Liver diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The incidence of GST1 0 in 41 liver biopsy samples from patients suffering from various liver diseases was investigated using polyacrylamide gel isoelectric focusing.
|
3570286 |
1987 |
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The glutathione transferase mu gene (GST1) and the debrisoquine hydroxylase gene (CYP2D6) are known to be polymorphic in the human population and have been associated with increased susceptibility to cancer.
|
1684153 |
1991 |
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The glutathione transferase mu gene (GST1) and the debrisoquine hydroxylase gene (CYP2D6) are known to be polymorphic in the human population and have been associated with increased susceptibility to cancer.
|
1684153 |
1991 |
Bronchogenic Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
For example CYP1A1, CYP2D6 and GST1 genotypes may have additive or multiplicative risks of bronchogenic carcinoma in cigarette smokers.
|
2011143 |
1991 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the first, involving a U.S. population sample, smokers with and without lung cancer were phenotyped, and a highly significant correlation between the absence of GSTM1-1 activity and adenocarcinoma of the lung was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1486868 |
1992 |
Mental Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Interictal behavioral disturbances: a search for molecular substrates.
|
1337448 |
1992 |
Depressive disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Interictal behavioral disturbances: a search for molecular substrates.
|
1337448 |
1992 |
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A homozygous gene deletion at the GST1 locus of genomic DNA isolated from peripheral blood was investigated for its relationship with several types of cancer using the polymerase chain reaction (PCR) technique.
|
1427788 |
1992 |
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since similar quantities of DNA adducts and GSTM1-1 activity have been shown to occur in bronchial and peripheral lung, however, the development of malignancy, which is usually in the bronchial region, presumably depends on additional factors that bring about promotion and progression, which are not necessarily affected by GSTM1 expression.
|
1486868 |
1992 |
Malignant neoplasm of stomach
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, GST1 deletion may be a possible genetic marker for early detection of a group at high risk of stomach cancer.
|
1427788 |
1992 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the first, involving a U.S. population sample, smokers with and without lung cancer were phenotyped, and a highly significant correlation between the absence of GSTM1-1 activity and adenocarcinoma of the lung was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1486868 |
1992 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, GST1 deletion may be a possible genetic marker for early detection of a group at high risk of stomach cancer.
|
1427788 |
1992 |
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A homozygous gene deletion at the GST1 locus of genomic DNA isolated from peripheral blood was investigated for its relationship with several types of cancer using the polymerase chain reaction (PCR) technique.
|
1427788 |
1992 |
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Since similar quantities of DNA adducts and GSTM1-1 activity have been shown to occur in bronchial and peripheral lung, however, the development of malignancy, which is usually in the bronchial region, presumably depends on additional factors that bring about promotion and progression, which are not necessarily affected by GSTM1 expression.
|
1486868 |
1992 |
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the first, involving a U.S. population sample, smokers with and without lung cancer were phenotyped, and a highly significant correlation between the absence of GSTM1-1 activity and adenocarcinoma of the lung was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1486868 |
1992 |
Adenocarcinoma of lung (disorder)
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In the first, involving a U.S. population sample, smokers with and without lung cancer were phenotyped, and a highly significant correlation between the absence of GSTM1-1 activity and adenocarcinoma of the lung was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1486868 |
1992 |
Malignant neoplasm of urinary bladder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, the GSTM1 0/0 genotype conferred a 70% increased risk of bladder cancer (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.2-2.5; P = .004).
|
8320745 |
1993 |
Bladder Neoplasm
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, the GSTM1 0/0 genotype conferred a 70% increased risk of bladder cancer (odds ratio [OR] = 1.7; 95% confidence interval [CI] = 1.2-2.5; P = .004).
|
8320745 |
1993 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, when the lung cancer patients were analysed by tumour type, a statistically significant increase in the GSTM1 null genotypes (62%; n = 71) was seen in the squamous cell carcinoma group, with an odds ratio of 2.1 (95% confidence interval 1.2-3.8).
|
8330369 |
1993 |
Malignant neoplasm of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the hypothesis of heritable GSTM1 deficiency as a host factor predisposing to lung cancer proved inappropriate.
|
8439946 |
1993 |
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1).
|
8103989 |
1993 |
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Previous data suggest that smokers lacking GSTM1 activity may be at greater risk of developing lung cancer.
|
8330369 |
1993 |
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.
|
8403204 |
1993 |