|
Lower respiratory tract infection
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, PM<sub>2.5</sub> exposure during the third trimester increased the risk of LRTIs at 1 year of age in cases with the GSTM1 null genotype (aRR, 1.26; 95% CI, 1.01-1.57; P for interaction .20).
|
31746563 |
2020 |
|
Cholelithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to investigate the role of genetic variants of GSTM1 and GSTT1 in GBC in Kashmir valley and cholelithiasis in the world.
|
31755784 |
2019 |
|
Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo, astrocyte-specific knockdown of GSTM1 in the prefrontal cortex attenuated microglia activation in brain inflammation induced by systemic injection of lipopolysaccharides (LPS).
|
30783009 |
2019 |
|
Sensorineural Hearing Loss (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Several studies have reported that antioxidant gene glutathione s-transferase M1 and T1 (GST M1 and T1) polymorphisms have a close relationship with the susceptibility to acquired SNHL, but other articles have reported opposite results.
|
30696891 |
2019 |
|
Kidney Calculi
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 and GSTT1 null genotypes are not a risk features for nephrolithiasis.
|
31445152 |
2019 |
|
Lymphoma, T-Cell, Cutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
Resistant CTCL exhibited high levels of histone acetylation, which correlated with increased expression of 338 genes (FDR < 0·05), including some novel to CTCL: BIRC5 (anti-apoptotic); RRM2 (cell cycle); TXNDC5, GSTM1 (redox); and CXCR4, LAIR2 (cell adhesion/migration).
|
31358475 |
2019 |
|
Endometriosis of ovary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Methylation levels of the GSTM1 promoter region in the ectopic and eutopic endometrial tissues of patients with ovarian endometriosis and the endometrial tissues of women without endometriosis were analysed by pyrosequencing.
|
30989213 |
2019 |
|
Nephrolithiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 and GSTT1 null genotypes are not a risk features for nephrolithiasis.
|
31445152 |
2019 |
|
Left ventricular diastolic dysfunction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of GSTT1/GSTM1 and ApoE variants with left ventricular diastolic dysfunction in thalassaemia major patients.
|
30095041 |
2019 |
|
Cardiovascular morbidity
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Subjects without cardiovascular morbidity with homozygous GSTM1 gene deletion appeared to be more susceptible to the effects of TPM<sub>10</sub>.
|
30716571 |
2019 |
|
High Grade Intraepithelial Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 null genotype was also related to high-grade intraepithelial neoplasia (HSIL) and cervical cancer risk (OR = 1.30 and OR = 1.78, respectively, P < .05).The GSTM1 null variant caused cervical lesions, especially among HPV infection cases and among the Chinese and Indian populations.
|
31593112 |
2019 |
|
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The combination of GSTM1 active and GSTT1 active genotype decreased the risk of ASD (OR = 0.126, 95%CI: 0.029-0.547, p = 0.006), as well as combination of GSTT1 active and GSTP1 llelle (OR = 0.170, 95%CI: 0.029-0.992, p = 0.049).
|
30824761 |
2019 |
|
Azoospermia, Nonobstructive
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, the GSTM1 null genotype was associated with OAT, but not NOA in Chinese populations.
|
30732132 |
2019 |
|
Oligoasthenozoospermia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, the GSTM1 null genotype was associated with OAT, but not NOA in Chinese populations.
|
30732132 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upregulated caveolin-1, filamin A, and cathepsin D combined with increased macrophagocytes and downregulated GSTM1 may be potential biomarkers and targets in the irreversibility CHD-PAH, and which may be useful in evaluating the operability and understanding the irreversibility of CHD-PAH.
|
29480151 |
2019 |
|
Acquired sensorineural hearing loss
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of Glutathione s-transferase M1 and T1 gene polymorphisms with the susceptibility to acquired sensorineural hearing loss: a systematic review and meta-analysis.
|
30696891 |
2019 |
|
IgE-mediated food allergy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Development of FA was associated with longer periods of breastfeeding (adjusted OR = 1.792, P = .03), and this dietary pattern was more significantly related to the development of FA in infants with the homozygous TT genotype of CD14 (rs2569190) and more than 1 copy of GSTM1 and GSTT1.
|
30930272 |
2019 |
|
Refractory anemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
An mRNA expression analysis revealed that CYP1A2 and CYP2E1 levels were decreased while those of NQO1, GPx, and GSTm1 increased after S. fruticosa and RA treatments.
|
28718679 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Frequencies of GSTM1 and GSTT1 deletions were shown to be 21.9% and 19.8%, respectively, in the HIV patients, and patients with homozygous deletion of both GSTM1 and GSTT1 were more likely to have their CD4+ count rising above 350 cells/mm3 (OR = 6.44, 95% CI = 0.81-51.49, p = 0.039) suggesting that patients with homozygous deletion of GSTM1 and GSTT1 genes have slower disease progression.
|
29795558 |
2018 |
|
Meniere Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Remarkably, GSTM1 might be a possible candidate gene for the diagnostic biomarker of MD and provides the basis for further biological and functional investigations.
|
29164594 |
2018 |
|
Chronic small plaque psoriasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the association between GSTs (GSTM1 and GSTT1) gene polymorphism in patients with chronic plaque psoriasis as a factor in the susceptibility and development of psoriasis.
|
29067933 |
2018 |
|
Metabolic Syndrome X
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our novel findings indicate GSTM1 could be a risk locus in MetS development and shed light novel scenarios on the role of glucose fluctuations in neurological impairments.
|
29452132 |
2018 |
|
Generalized vitiligo
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study showed a significant trend towards an association with the combination of the GSTM1/GSTT1 double null polymorphism and generalized vitiligo.
|
29641697 |
2018 |
|
AIDS (Disease)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study sought to investigate the association between homozygous deletion of GSTM1 and GSTT1 genes (both null deletion) with HIV/AIDS disease progression in Ghanaian patients.
|
29795558 |
2018 |
|
Toxic Epidermal Necrolysis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 null genotype was more frequent in the cases with SJS/TEN than in the controls (OR = 2.94, P = 0.027).
|
28689274 |
2017 |