|
Hepatitis C
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to test the hypothesis that genetic variants of TBX21 (T cell specific T-box transcription factor) were associated with the outcomes of HCV infection and F protein generation.
|
25759111 |
2015 |
|
Hepatitis C
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Results showed that TBX21 rs4794067 variant genotypes significantly correlated with increased risk of HCV chronic infection (dominant model: OR = 5.690, 95% CI = 2.024-16.000) and susceptibility (dominant model: OR = 5.658, 95% CI = 2.514-12.735).
|
29399747 |
2018 |
|
Neoplasm Metastasis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
|
22416188 |
2012 |
|
Neoplasm Metastasis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
TBX21 gene -1514 and -1993 polymorphisms might be counted as the influential factors for lymph node and distant metastasis to ESCC.
|
25577251 |
2015 |
|
Aplastic Anemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to AA in the Chinese population.
|
22133489 |
2012 |
|
Dermatitis, Atopic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
TBX21 SNP rs11079788 carriers developed less symptoms of atopic dermatitis at 3 years of age (p = 0.03).
|
22303482 |
2012 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests the first evidence of an association between type 1 diabetes and polymorphisms in the T-bet gene, and that variation in T-bet transcriptional activity may play a role in the development of type 1 diabetes, possibly through the effect on IFN-gamma production in Th1 cells.
|
15241679 |
2004 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
PSMA tumor volumes (PSMA-TV) and tumor lesion PSMA expressions (TL-PSMA) were calculated with a semi-automatic program on Ga-68 PSMA I&T PET/CT images that were obtained before and after Lu-177 PSMA I&T therapies with 19 patients.
|
31214958 |
2019 |
|
Peripheral T-Cell Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Additionally, the 2 IHC-defined subtypes were significantly associated with distinct morphological features (P < .001), and there was a significant enrichment of an activated CD8+ cytotoxic phenotype in the PTCL-TBX21 subtype (P = .03).
|
31562134 |
2019 |
|
Peripheral T-Cell Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The PTCL-TBX21 subgroup had fewer CNAs, primarily targeting cytotoxic effector genes, and was enriched in mutations of genes regulating DNA methylation.
|
30782609 |
2019 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the polymorphisms of the TBX21 gene might be associated with the susceptibility to male RA patients.
|
19287198 |
2009 |
|
Eczema
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
TBX21 SNP rs11079788 carriers developed less symptoms of atopic dermatitis at 3 years of age (p = 0.03).
|
22303482 |
2012 |
|
Inflammatory Bowel Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
Malignant neoplasm of stomach
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers.
|
20193034 |
2010 |
|
Malignant neoplasm of stomach
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
|
22416188 |
2012 |
|
Systemic Scleroderma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Multiple SNPs in TBX21 and STAT4 were found to be associated with SSc.
|
19950257 |
2009 |
|
Systemic Scleroderma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, gene-gene interaction studies suggest that IRF5, STAT4, and BANK1 as well as TBX21 and STAT4 interact with regard to scleroderma susceptibility.
|
20090527 |
2010 |
|
Ankylosing spondylitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
TBX21 encodes T-bet, a transcription factor, lying within a locus with genome-wide significant association with AS.
|
27125523 |
2017 |
|
Allergic asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms rs4794067 and rs16947078 of TBX21 were found to be associated with acetylsalicylic acid-induced and allergic asthma, respectively.
|
25056814 |
2014 |
|
Autoimmune Chronic Hepatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population.
|
20977921 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.
|
29358858 |
2017 |
|
Hepatitis C, Chronic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of IL-28B, TBX21 gene polymorphisms and predictors of virological response for chronic hepatitis C.
|
29399747 |
2018 |
|
Autoimmune hepatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding.
|
29358858 |
2017 |
|
Autoimmune hepatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population.
|
20977921 |
2011 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sixty-four patients with probable or possible AD associated with DM were classified using PiB (detects amyloid, A) and PBB3 (detects tau, T) PET studies.
|
31356213 |
2019 |