CD209, CD209 molecule, 30835

N. diseases: 57; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1834752
Disease: MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) 		0.300 Biomarker disease CTD_human
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.020 AlteredExpression disease LHGDN Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease. 12594843 2003
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 AlteredExpression disease LHGDN L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. 15371595 2004
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.070 Biomarker group BEFREE In the early events of human immunodeficiency virus type 1 (HIV-1) infection, immature dendritic cells (DCs) expressing the DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) receptor capture small amounts of HIV-1 on mucosal surfaces and spread viral infection to CD4(+) T cells in lymph nodes (22, 34, 45). 15452205 2004
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 Biomarker disease BEFREE In the early events of human immunodeficiency virus type 1 (HIV-1) infection, immature dendritic cells (DCs) expressing the DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) receptor capture small amounts of HIV-1 on mucosal surfaces and spread viral infection to CD4(+) T cells in lymph nodes (22, 34, 45). 15452205 2004
CUI: C3714514
Disease: Infection
Infection 		0.060 Biomarker group LHGDN Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. 15494514 2004
CUI: C0004030
Disease: Aspergillosis
Aspergillosis 		0.010 Biomarker disease LHGDN Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. 15494514 2004
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.310 Biomarker group CTD_human Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. 15564514 2004
CUI: C4505456
Disease: HIV Coinfection
HIV Coinfection 		0.300 Biomarker disease CTD_human Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. 15564514 2004
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 GeneticVariation disease BEFREE Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection. 15564514 2004
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.400 Biomarker disease BEFREE These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. 15838506 2005
CUI: C0011311
Disease: Dengue Fever
Dengue Fever 		0.400 Biomarker disease CTD_human These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. 15838506 2005
CUI: C0019100
Disease: Severe Dengue
Severe Dengue 		0.050 Biomarker disease BEFREE These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. 15838506 2005
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary 		0.360 Biomarker disease CTD_human Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. 16379498 2006
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 GeneticVariation disease BEFREE After exclusion of significant population stratification in our cohort, we observed an association between two CD209 promoter variants (-871G and -336A) and decreased risk of developing tuberculosis. 16379498 2006
CUI: C3714514
Disease: Infection
Infection 		0.060 Biomarker group LHGDN DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages. 16424204 2006
CUI: C1512508
Disease: Human herpesvirus 8 infection
Human herpesvirus 8 infection 		0.010 Biomarker disease BEFREE In this study, we show that dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209) is a receptor for HHV-8 infection of myeloid DCs and macrophages. 16424204 2006
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.040 Biomarker disease BEFREE It has been proposed that DC-SIGN targets HIV to a nondegradative compartment within DCs and DC-SIGN-expressing cells, allowing incoming virus to persist for several days before infecting target cells. 16501104 2006
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.010 Biomarker disease LHGDN DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells. 16641270 2006
CUI: C0023343
Disease: Leprosy
Leprosy 		0.010 Biomarker disease BEFREE Here we sought to evaluate whether DC-SIGN interacts with the leprosy bacillus, Mycobacterium leprae, and whether DC-SIGN genetic variation influences the susceptibility and/or pathogenesis of the disease. 16698431 2006
CUI: C0267818
Disease: Bile duct proliferation
Bile duct proliferation 		0.010 Biomarker disease BEFREE Novel differentially expressed genes in AH in comparison to ND and AS included claudins, osteopontin, CD209, selenoprotein and genes related to bile duct proliferation. 16797773 2006
CUI: C3714514
Disease: Infection
Infection 		0.060 Biomarker group LHGDN DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes. 16839201 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.010 GeneticVariation disease BEFREE Initially, the case-control and familial studies did not find any association of the -336 A/G CD209 genetic variant with CD susceptibility. 16865785 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.010 GeneticVariation disease LHGDN Initially, the case-control and familial studies did not find any association of the -336 A/G CD209 genetic variant with CD susceptibility. 16865785 2006
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 GeneticVariation disease LHGDN Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis. 17055357 2006