|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results indicate that HLA-DQB1 and not HLA-DRB1 plays an important role in sarcoidosis susceptibility in African Americans.
|
12554629 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Susceptibility to the development of sarcoidosis has been demonstrated to be associated with HLA-DR5, -DR6, and -DR8 encoded by the DRB1 gene.
|
7742275 |
1995 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association of the HSP(+2437)-C allele with sarcoidosis and LS appeared to be independent of the presence of DRB1*03, although this HLA specificity was associated with LS manifestation.
|
16611259 |
2006 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to further investigate associations between HLA-DRB1 alleles and the risk for extra-pulmonary manifestations (EPMs), i.e. engagement of the skin, superficial lymph nodes, eyes, nervous system, kidneys, hypercalcemia, parotid and salivary glands, heart, liver, spleen and bone marrow in Scandinavian sarcoidosis patients.
|
24641503 |
2014 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease.
|
17559577 |
2007 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found a highly significant correlation of HLA-DRB1*11 or -DRB1*15 alleles and/or the presence of M. tuberculosis DNA to a chronic disease course, whereas HLA-DRB1*03 or -DRB1*04 alleles combined with the absence of M. tuberculosis DNA were associated with an acute sarcoidosis (p = 0.009).
|
15881283 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The data suggest that the LTAlpha and HLA-DRB1 genes themselves or a gene located nearby contributes to the susceptibility to sarcoidosis and that TNF-308*A, LTA+252*G and HLA-DRB1*03 alleles are associated (directly or via linkage with unknown causative locus) with LS as a specific manifestation of the disease.
|
15713215 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Löfgren's syndrome is a common sarcoidosis phenotype in the Dutch and is strongly associated with the DRB1*0301 allele.
|
20685690 |
2010 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, this difference might be explained by a secondary association with HLA-DRB1*08 in the HLA-DRB1 gene, which is thought to be the gene primarily responsible for susceptibility to sarcoidosis.
|
9458120 |
1997 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1-F(47) was the amino acid residue most associated with sarcoidosis and independently associated with sarcoidosis in whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
LHGDN |
In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS).
|
15019280 |
2004 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results support the hypothesis that HLA-A, -B, and -DRB1 polymorphisms may play a role in susceptibility and manifestation of sarcoidosis.
|
21513758 |
2011 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results support the importance of HLA-DRB1 as a predisposing gene for sarcoidosis.
|
22074998 |
2012 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis.
|
30009963 |
2018 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the patients with secondary EN, the patient subgroup with sarcoidosis exhibited a significantly increased frequency of HLA-DRB1* 13 compared with healthy controls.
|
11764214 |
2001 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*04 seems to protect against overall sarcoidosis but appears to be a significant risk factor for ocular sarcoidosis as well as for other manifestations associated with HS.
|
21565911 |
2011 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The overrepresentation of TNF-308*A, LTAlpha+252*G and HLA-DRB1*03 allele carriers was found in a subgroup of sarcoidosis patients presenting with Lofgren's syndrome (LS) by comparison with the subgroup of patients without LS (NLS; phenotype frequency LS vs NLS: 68.8 vs 37.1% for TNF-308*A, 93.8 vs 66.3% for LTA+252*G and 68.8 vs 21.3% for DRB1*03).
|
15713215 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis.
|
29229112 |
2017 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Results of in silico binding analyses showed that DRB1*03:01 consistently demonstrated the highest binding affinities for six bacterial peptides previously found in sarcoidosis granulomas, whereas *12:01 displayed the lowest binding affinities.
|
25506722 |
2015 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients.
|
20187937 |
2010 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our studies implicated that the HLA-DRB1 allele is a major contributing genetic factor in the development of sarcoidosis in Japan.
|
22991420 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
|
22952805 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In a retrospective case-control study, TNF-alpha G-308A, TNF-alpha G-238A, lymphotoxin-alpha (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients.
|
20070603 |
2010 |