|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the HLA-alleles responsible for the susceptibility to sarcoidosis are located at the HLA-DRB1 locus rather than the HLA-DRB3, -DQA1 and -DQB1 loci.
|
8085259 |
1994 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Susceptibility to the development of sarcoidosis has been demonstrated to be associated with HLA-DR5, -DR6, and -DR8 encoded by the DRB1 gene.
|
7742275 |
1995 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our finding of a high frequency of DRB1*08 (which lacks the DRB3 gene encoding the DR52 antigen) in patients living in both eastern Japan and in Hokkaido, confirms that it is the HLA-DRB1 locus, rather than that of the HLA-DRB3, -DQA1, or -DQB1, which determines the susceptibility to sarcoidosis.
|
9130059 |
1996 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The significantly increased frequency of the DR8 (DRB1*08) haplotype, which lacks the DRB3 gene encoding DR52 antigen, suggested that the DR5 (DRB1*11), DR6 (DRB1*14) and DR8 (DRB1*08) of the DRB1 alleles may determine the susceptibility to sarcoidosis among the Japanese.
|
8739505 |
1996 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, this difference might be explained by a secondary association with HLA-DRB1*08 in the HLA-DRB1 gene, which is thought to be the gene primarily responsible for susceptibility to sarcoidosis.
|
9458120 |
1997 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These studies support the thesis that one of the major genetic factors controlling the development of sarcoidosis is located within the DRB1 locus in the HLA class II region.
|
9349405 |
1997 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Sarcoidosis is a systemic granulomatous disease and the DRB1 gene of the DR subregion has been implicated for determining the genetic susceptibility to the disease.
|
9062964 |
1997 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the patients with secondary EN, the patient subgroup with sarcoidosis exhibited a significantly increased frequency of HLA-DRB1* 13 compared with healthy controls.
|
11764214 |
2001 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis.
|
11588003 |
2001 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.
|
11169267 |
2001 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB3*0101 as well as DRB1*0301 positive sarcoidosis patients may have the capacity to present specific sarcoidosis associated antigens in such a way that AV2S3+ CD4+ T cells are stimulated preferentially, generating lung restricted AV2S3+ T cell expansions.
|
11923555 |
2002 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results indicate that HLA-DQB1 and not HLA-DRB1 plays an important role in sarcoidosis susceptibility in African Americans.
|
12554629 |
2003 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1-F(47) was the amino acid residue most associated with sarcoidosis and independently associated with sarcoidosis in whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Further, multivariate logistic regression analysis revealed that the presence of DRB1*11(odds ratio [OR] 9) and DRB1*14 (OR 7), and absence of DRB1*07 (OR 63 and DQB1*0201(OR 3) alleles, were independent predictors of sarcoidosis.
|
12600814 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
LHGDN |
In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS).
|
15019280 |
2004 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).
|
15019280 |
2004 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found a highly significant correlation of HLA-DRB1*11 or -DRB1*15 alleles and/or the presence of M. tuberculosis DNA to a chronic disease course, whereas HLA-DRB1*03 or -DRB1*04 alleles combined with the absence of M. tuberculosis DNA were associated with an acute sarcoidosis (p = 0.009).
|
15881283 |
2005 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The data suggest that the LTAlpha and HLA-DRB1 genes themselves or a gene located nearby contributes to the susceptibility to sarcoidosis and that TNF-308*A, LTA+252*G and HLA-DRB1*03 alleles are associated (directly or via linkage with unknown causative locus) with LS as a specific manifestation of the disease.
|
15713215 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The overrepresentation of TNF-308*A, LTAlpha+252*G and HLA-DRB1*03 allele carriers was found in a subgroup of sarcoidosis patients presenting with Lofgren's syndrome (LS) by comparison with the subgroup of patients without LS (NLS; phenotype frequency LS vs NLS: 68.8 vs 37.1% for TNF-308*A, 93.8 vs 66.3% for LTA+252*G and 68.8 vs 21.3% for DRB1*03).
|
15713215 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association of the HSP(+2437)-C allele with sarcoidosis and LS appeared to be independent of the presence of DRB1*03, although this HLA specificity was associated with LS manifestation.
|
16611259 |
2006 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different.
|
18038917 |
2006 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent studies in sarcoidosis have identified association of a single nucleotide polymorphism (SNP) rs2076530 within BTNL2, a potential T-cell inhibitor, independent of the known DRB1 association.
|
16984233 |
2006 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease.
|
17559577 |
2007 |