|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The association of the HSP(+2437)-C allele with sarcoidosis and LS appeared to be independent of the presence of DRB1*03, although this HLA specificity was associated with LS manifestation.
|
16611259 |
2006 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to further investigate associations between HLA-DRB1 alleles and the risk for extra-pulmonary manifestations (EPMs), i.e. engagement of the skin, superficial lymph nodes, eyes, nervous system, kidneys, hypercalcemia, parotid and salivary glands, heart, liver, spleen and bone marrow in Scandinavian sarcoidosis patients.
|
24641503 |
2014 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease.
|
17559577 |
2007 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, we found a highly significant correlation of HLA-DRB1*11 or -DRB1*15 alleles and/or the presence of M. tuberculosis DNA to a chronic disease course, whereas HLA-DRB1*03 or -DRB1*04 alleles combined with the absence of M. tuberculosis DNA were associated with an acute sarcoidosis (p = 0.009).
|
15881283 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Löfgren's syndrome is a common sarcoidosis phenotype in the Dutch and is strongly associated with the DRB1*0301 allele.
|
20685690 |
2010 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, this difference might be explained by a secondary association with HLA-DRB1*08 in the HLA-DRB1 gene, which is thought to be the gene primarily responsible for susceptibility to sarcoidosis.
|
9458120 |
1997 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1-F(47) was the amino acid residue most associated with sarcoidosis and independently associated with sarcoidosis in whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results support the hypothesis that HLA-A, -B, and -DRB1 polymorphisms may play a role in susceptibility and manifestation of sarcoidosis.
|
21513758 |
2011 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The overrepresentation of TNF-308*A, LTAlpha+252*G and HLA-DRB1*03 allele carriers was found in a subgroup of sarcoidosis patients presenting with Lofgren's syndrome (LS) by comparison with the subgroup of patients without LS (NLS; phenotype frequency LS vs NLS: 68.8 vs 37.1% for TNF-308*A, 93.8 vs 66.3% for LTA+252*G and 68.8 vs 21.3% for DRB1*03).
|
15713215 |
2005 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis.
|
29229112 |
2017 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients.
|
20187937 |
2010 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our studies implicated that the HLA-DRB1 allele is a major contributing genetic factor in the development of sarcoidosis in Japan.
|
22991420 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
|
22952805 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In a retrospective case-control study, TNF-alpha G-308A, TNF-alpha G-238A, lymphotoxin-alpha (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients.
|
20070603 |
2010 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These studies support the thesis that one of the major genetic factors controlling the development of sarcoidosis is located within the DRB1 locus in the HLA class II region.
|
9349405 |
1997 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis.
|
11588003 |
2001 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the HLA-alleles responsible for the susceptibility to sarcoidosis are located at the HLA-DRB1 locus rather than the HLA-DRB3, -DQA1 and -DQB1 loci.
|
8085259 |
1994 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
BTNL2 haplotype 4, tagged by the rs2076530 G allele, also remained associated with non-Löfgren sarcoidosis after adjusting for HLA-DRB1 alleles (OR 0.37, P = 0.016).
|
17661910 |
2007 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
BTNL2 rs206530 A allele frequencies were significantly higher in sarcoidosis with no linkage disequilibrium with HLA-DRB1 alleles, except in the subgroup of patients with Löfgren syndrome where the determinant allele was HLA-DRB1*03.
|
23017494 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Among sarcoidosis patients, the HLA A*23, A*80, B*08, B*41, DQB1*05 and DRB1*14 antigens tended to be more common than in the controls, whereas the B*44, B*45, B*51, B*58, DRB1*15 and DRB1*16 alleles were more frequently found in control subjects than in the sarcoidosis patients.
|
23911360 |
2013 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our finding of a high frequency of DRB1*08 (which lacks the DRB3 gene encoding the DR52 antigen) in patients living in both eastern Japan and in Hokkaido, confirms that it is the HLA-DRB1 locus, rather than that of the HLA-DRB3, -DQA1, or -DQB1, which determines the susceptibility to sarcoidosis.
|
9130059 |
1996 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Together, these studies reveal the presence of linked <i>in situ</i> recognition of vimentin by both T- and B-cells in HLA-DRB1*03<sup>+</sup> sarcoidosis patients, associated with a selective humoral immune response to the vimentin C-terminus.
|
30038611 |
2018 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We performed abdominal ultrasonography to evaluate the prevalence and extent of splenomegaly and genotyped for HLA-DRB1 and DQB1 using allele or allele group specific primers in polymerase-chain-reaction on 138 Japanese sarcoidosis patients as case comparison study.
|
17875181 |
2007 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent studies in sarcoidosis have identified association of a single nucleotide polymorphism (SNP) rs2076530 within BTNL2, a potential T-cell inhibitor, independent of the known DRB1 association.
|
16984233 |
2006 |