|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In subtypes of DR4, there was a trend of increase in the gene frequency of DRB1 0405 in patients with AIH versus healthy controls (21.9% vs 6.3%, P=0.04, but P(c) =0.08).
|
11819862 |
2001 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present findings suggest that the gene or genes conferring susceptibility to AIH lie in the region centromeric to the HLA A locus between HLA C and DRB1.
|
9328330 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
According to the univariate analysis, overlapping features of autoimmune hepatitis (rPSC in 5/5, <i>P</i> ≤ 0.05) and <i>HLA-DRB1*07</i> in the donor (rPSC in 10/15, <i>P</i> ≤ 0.05) represent other potential risk factors for rPSC, while the <i>HLA-DRB1*04</i> (rPSC in 0/6, <i>P</i> ≤ 0.05), <i>HLA-DQB1*03</i> (rPSC in 1/11, <i>P</i> ≤ 0.05), and <i>HLA-DQB1*07</i> (rPSC in 0/7, <i>P</i> ≤ 0.05) recipient alleles may have protective roles.
|
30487703 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The principal HLA alleles associated with type 1 autoimmune hepatitis in Britain and North America are DRB1*0301 and DRB1*0401.
|
10807521 |
2000 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the DR4-specific sequence (Val 11 and His 13 at amino acid positions 11 and 13, respectively), but not particular Dw-associated DR4 sequence, in the first domain of the DRB1 chain contributes to susceptibility to autoimmune hepatitis among Japanese.
|
1350267 |
1992 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM.
|
21067577 |
2010 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibody profile defines AIH types 1 and 2 in addition to strong association with HLA-DRB1.
|
26693492 |
2015 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genetic AIH risk factor HLA DRB1*03:01 was more frequent in younger patients, and DRB1*04:01 was more frequent in middle-aged patients without an obvious link to virus seropositivities.
|
30487523 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also the role of HLA-DRB1 genotype has not been evaluated, though it's associated with fibrosis in autoimmune hepatitis.
|
27333038 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, DRB1(∗)11 was less frequent in AIH patients.
|
26780502 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA alleles appear to influence the exact phenotype-the most interesting apparent association being between HLA-DRB1*0301-DQB1*0201, liver-kidney microsome autoantibodies (anti-CYP1A2), and autoimmune hepatitis.
|
22344197 |
2012 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The detailed internal replication and parallel analyses allowed the observation of two of eight AIH cases carrying a rare allele genotype for a previously described AIH-associated gene (FTCD), plus multiple occurrences of known HLA-DRB1 alleles associated with AIH (HLA-DRB1-03:01:01, 13:01:01 and 7:01:01).
|
29995946 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic susceptibility to autoimmune hepatitis is strongly associated with HLA-DRB1 alleles.
|
20933106 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54-DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis.
|
11984513 |
2002 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of deleterious alleles in TNFAIP3 was higher in the AIH subset without the DRB1 risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55-16.74).
|
31138864 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.
|
17510796 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2×10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006).
|
24956105 |
2014 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study does not support the association of HLA-DRB1*04:04:01 with the susceptibility to AIH in Mexican population.
|
31570816 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most influential gene on type 1 AIH pathogenesis in Japanese is the HLA-DRB1.
|
15763345 |
2005 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility for type 1 autoimmune hepatitis has been associated with the major histocompatibility alleles DRB1*0301, DRB3*0101, DRB1*0401, and DRB4*0103, whereas the DRB1*1501 allele may protect from the disease.
|
9021941 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the HLA-DRB1*0403 allele differed among Japanese patients with AIH according to the presence or absence of anti-gAChR antibodies.
|
26807576 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the HLA-DRB1*03:01 and HLA-DRB1*04:01 alleles are both independently associated with the aggregate diagnostic IAIHG score in type-1 AIH patients, but are not essential for AIH development.
|
25611558 |
2015 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that susceptibility to AIH remains primarily linked to the HLA-DRB1 locus, and suggest that the association of AIH with TNFA*2 previously observed in whites might be secondary to a linkage disequilibrium with HLA-DRB1*0301.
|
11495038 |
2001 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report on a 55-year-old woman in whom AIH developed during the convalescence period of serologically proven acute viral hepatitis type A. HLA class II DRB1*0401, which was reported to be associated with AIH with a moderate coarse and late appearance in life, was found in this patient.
|
10548341 |
1999 |