|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Our data suggest an association between MHC class I and class II (HLA-A*29, HLA-B*51, HLA-DRB1*15, and HLA-DQB1*06) and susceptibility to SLE in the Saudi population.
|
23793423 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
HLA-DRB1*13 was associated with AVE. All measured specificities of aPL-cardiolipin IgG and IgM, β2-glycoprotein-1 IgG, prothrombin (PT) IgG and a positive lupus anticoagulant test were associated with HLA-DRB1*04-while HLA-DRB1*13 was associated with IgG antibodies (β2-glycoprotein-1, cardiolipin and PT).
|
22893315 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Advances in lupus genetics.
|
23917156 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes.
|
23407388 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.
|
22654485 |
2012 |
|
Sarcoidosis
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles.
|
22991420 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
The most strongly associated SNP with SLE was the rs9271366 (odds ratio, OR = 1.70, p = 5.6 × 10(-5)) near the HLA-DRB1 gene.
|
21695597 |
2011 |
|
Narcolepsy
|
0.700 |
Biomarker
|
disease |
CTD_human |
To further define the genetic basis of narcolepsy risk, we performed a genome-wide association study (GWAS) in 562 European individuals with narcolepsy (cases) and 702 ethnically matched controls, with independent replication in 370 cases and 495 controls, all heterozygous for DRB1*1501-DQB1*0602.
|
20711174 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
|
Narcolepsy
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1( *)1501/DQB1( *)0602 finding.
|
19410508 |
2009 |
|
Narcolepsy
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
The susceptibility alleles found in Mexicans with narcolepsy are also present in Japanese and Caucasians; DRB1*04 linked protection has also been shown in Koreans.
|
18706091 |
2008 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.700 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*0301 and DQA1*0501 in RA.
|
11436868 |
2001 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Narcolepsy-Cataplexy Syndrome
|
0.530 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
|
20711174 |
2010 |
|
Narcolepsy-Cataplexy Syndrome
|
0.530 |
SusceptibilityMutation
|
disease |
ORPHANET |
Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1( *)1501/DQB1( *)0602 finding.
|
19410508 |
2009 |
|
Narcolepsy-Cataplexy Syndrome
|
0.530 |
SusceptibilityMutation
|
disease |
ORPHANET |
The purpose of the present study was to investigate the association of HLA class II DRB1/DQB1 alleles with narcolepsy-cataplexy in Mexican Mestizo patients.
|
18706091 |
2008 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
CTD_human |
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
|
26168013 |
2015 |
|
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Furthermore, it highlights a potential contribution to MS risk also from interisotypic combination between products of neighboring HLA-DR15 haplotype alleles, in this case the DQA1/DRB1 combination.
|
25911099 |
2015 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.
|
22286218 |
2012 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
|
19898480 |
2009 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
The HLA haplotype DRB1*15-DPB1*05 can be a susceptibility gene marker for the development of TDI-induced asthma among the exposed workers in the Korean population.
|
16792590 |
2006 |