|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genetic alterations in rat colon tumors induced by heterocyclic amines.
|
8608549 |
1996 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of APC in patients with Turcot syndrome (colon cancer and medulloblastoma), was well as somatic mutations of APC, beta-catenin, and Axin in sporadic medulloblastomas (MBs) have shown the importance of WNT signaling in the pathogenesis of MB.
|
15077159 |
2004 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Heme induces multiple genetic alterations by regulating WNT signalling pathway and causing mutations in major colon cancer genes such as APC, TP53 and KRAS.
|
29759553 |
2018 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) into the last exon of the APC gene in a colon cancer.
|
1310068 |
1992 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a de novo germline mutation of APC as the causal variant in a Chinese family with inheritable colon cancer by the next generation sequencing.
|
24735542 |
2014 |
|
Malignant tumor of colon
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that the expression status of adenomatous polyposis coli (APC) protein determines the relative sensitivity of colon cancer cells to HDAC inhibitor-induced apoptosis.
|
16982769 |
2006 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
High-resolution banding studies indicated that the deletion in the patient with polyposis spans the region 5q21-q22, which includes APC, a gene involved in familial adenomatous polyposis and sporadic colon cancer.
|
1315124 |
1992 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemical analyses of colon cancer in I1307K APC mutation carriers compared with noncarriers.
|
12822869 |
2003 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
In a series of 11 microsatellite stable (MSS) and 9 microsatellite unstable (MSI) colon cancer cell lines and primary colon carcinomas (25 MSS and 28 MSI) with known ploidy stem line and APC, KRAS, and TP53 mutation status, we analyzed the promoter methylation of the following genes: hMLH1, MGMT, p16INK4a (CDKN2A alpha-transcript), p14ARF (CDKN2A beta-transcript), APC, and E-cadherin (CDH1).
|
15476557 |
2004 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, recent data on APC gene mutations challenges the existing paradigm for colon cancer carcinogenesis and precursor lesions, which may in turn have clinical implications for cancer prevention.
|
18482722 |
2008 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In blinded specimens and colon cancer cell lines with defined mutations, ColoSeq correctly identified 28/28 (100%) pathogenic mutations in MLH1, MSH2, MSH6, PMS2, EPCAM, APC, and MUTYH, including single nucleotide variants (SNVs), small insertions and deletions, and large copy number variants.
|
22658618 |
2012 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
In order to assess whether chronic infection with T. muris does indeed influence the development of cancer hallmarks, both wild type mice and colon cancer model (APC min/+) mice were infected with this parasite.
|
28650985 |
2017 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, we did not detect any functional mutations of the APC gene in a wide variety of tumors except for a colon cancer cell line, suggesting that alterations of the APC gene do not have a major role in the development of lung and renal cancers, various types of sarcomas, or hematological malignancies.
|
9083931 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer.
|
11237529 |
2001 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
It is important to evaluate the effects of proposed interventions to reduce the risk of disease among carriers of a highly penetrant mutation, such as the mutations in BRCA1 and BRCA2 for breast and ovarian cancers or in APC and MLH1 or MSH2 for colon cancer.
|
15316055 |
2004 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer.
|
10090594 |
1999 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutant forms of beta-catenin have been discovered in colon cancers that retain wild-type APC genes, and also in melanomas, medulloblastomas, prostate cancer and gastric and hepatocellular carcinomas.
|
10201372 |
1999 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutation analysis was performed for p53 in eight colon cancers and for APC and p53 in 22 rectal cancers.
|
11592095 |
2001 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutation in the adenomatous polyposis coli (APC) gene is considered to be one of the earliest events in the colon cancer development.
|
15769611 |
2005 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in APC or in beta-catenin, which are common in colon cancer, lead to constitutive activation of beta-catenin/Tcf-dependent signaling. alpha-Catenin is also found in some colon cancer cell nuclei, and loss of its expression correlates with increased beta-catenin/Tcf transcriptional activity.
|
15051498 |
2004 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in APC or CTNNB1 are highly frequent in colon cancer and cause aberrant stabilization of CTNNB1, which activates the transcription of Wnt target genes by binding to chromatin via the TCF/LEF transcription factors.
|
24651522 |
2014 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers.
|
1355210 |
1992 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers, directly target the proto-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling.
|
12414619 |
2002 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers.
|
8990193 |
1997 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.
|
10383901 |
1999 |