|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene.
|
12034317 |
2002 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest APC mutations alter regulation of both beta- and gamma-catenin, perhaps explaining why the frequency of APC mutations in colon cancer far exceeds that of beta-catenin mutations.
|
10837025 |
2000 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Peptide-mediated precipitation experiments showed that anti-APCp1 bound and sequestered wild-type and mutant APC proteins in extracts of human colon cancer cell lines.
|
9663391 |
1998 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Promoter hypermethylation was frequently detected in more than 40% of colonic cancers and adenomas in APC, ATM, HLTF, MGMT and hMLH1 genes (p < 0.0001 vs. normal).
|
15386372 |
2004 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation.
|
16042576 |
2005 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.
|
14679305 |
2004 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
Secretory clusterin (sCLU) is a stress-induced, pro-survival glycoprotein elevated in early-stage cancers, in particular in APC/Min-defective colon cancers. sCLU is upregulated after exposure to various cytotoxic agents, including ionizing radiation (IR), leading to a survival advantage.
|
21460853 |
2011 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since the Adenomatous Polyposis Coli (APC) gene is mutated in the majority of human colon cancers and often occurs simultaneously with PIK3CA mutations, we sought to better understand the interaction between APC and PIK3CA mutations in the mammalian intestine.
|
23708654 |
2014 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations of the APC gene are found in 80% of all colon cancers.
|
15131404 |
2004 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Somatic mutations of the APC gene have also been identified in the majority of sporadic colorectal carcinomas, and mutation of the APC gene appears to be an early step in the initiation of colon cancer.
|
21518821 |
2011 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
|
7846077 |
1995 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Studies such as those on APC I1307K and CHEK2 1100delC may suggest the way forward for the identification of 'breast-colon cancer' genes.
|
14574178 |
2001 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.
|
26335331 |
2015 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Survivin-induced Aurora-B kinase activation: A mechanism by which APC mutations contribute to increased mitoses during colon cancer development.
|
21057000 |
2010 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an inherited syndrome of colon cancer predisposition known as familial adenomatous polyposis coli (FAP).
|
10784639 |
2000 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) protein tumor suppressor is mutated in the majority of colon cancers.
|
18160396 |
2008 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The APC gene, mutations in which are responsible for the inherited colon cancer syndrome adenomatous polyposis coli (APC), is described as a tumor suppressor gene.
|
7882361 |
1995 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer.
|
7903889 |
1993 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer.
|
8381581 |
1993 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
The APC/MCC gene (Familial Adenomatous Polyposis) at 5q21 plays a role in colon cancer carcinogenesis.
|
9182290 |
1996 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
BEFREE |
The adenomatous polyposis coli gene (APC gene) originally was identified as a tumor suppressor gene in colon cancer.
|
15754020 |
2005 |
|
Malignant tumor of colon
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The apparently low incidence of colon cancer in the African population may be ascribed either to the rare occurrence of the 'second hit' needed for polyp formation or to a lower incidence of mutations in the APC gene.
|
12000364 |
2002 |
|
Malignant tumor of colon
|
0.500 |
Biomarker
|
disease |
CTD_human |
The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.
|
25200834 |
2014 |
|
Malignant tumor of colon
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
The correlation between the methylation of APC gene and pathological parameters of colon cancer patients was analyzed.
|
28781669 |
2017 |
|
Malignant tumor of colon
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated.
|
27064876 |
2016 |