|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HA-RAS mutations are rare in human SCC, but HA-RAS-mutated tumors appear in melanoma patients treated with B-raf inhibitors, indicating that initiated, HA-RAS-mutated stem cells also reside in human skin.
|
23266722 |
2013 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Characteristic codon 61 mutations in the Ha-ras gene were found in most of the papillomas and SCCs induced by DMBA and TPA in transgenic as well as nontransgenic mice.
|
9115586 |
1997 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We analysed the presence of EGFR and concomitant HRAS mutations in a German cohort of 31 patients with cutaneous SCC by direct sequencing of EGFR and SNaPshot analysis of concomitant RAS mutations.
|
21771097 |
2011 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This investigation of oral squamous carcinoma in five individuals revealed that four of the patients were constitutionally heterozygous at the c-Ha-ras-1 locus and that the tumour from one patient had lost that heterozygosity.
|
2568483 |
1989 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Both HRAS mutant SCC and BCC biopsies were HPV- and CMV-positive, as well.
|
19849697 |
2010 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.
|
27074337 |
2016 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Topographic genotyping with subsequent polymerase chain reaction (PCR) and sequence analysis of K-ras-2 showed mutations in significantly fewer cases of PC (9%, 2 of 22 cases) than in AdC (36%, 35 of 97 cases) or SqC (0%, 0 of 42 cases) (P < .001).
|
8853037 |
1996 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Ha-ras mutations (61A-->T transversions in the second position) were found in five of 29 (17%) samples (one dysplasia and four SCCs).
|
8519419 |
1995 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that all three NIH 3T3 transformants, 11 of 24 (46%) SCCs, and 5 of 16 (31%) BCCs contained mutations at the second position of Ha-ras codon 12 (GGC----GTC), predicting a glycine-to-valine amino acid substitution, whereas only 1 of 40 skin cancers (an SCC) displayed a mutation in the first position of Ki-ras codon 12 (GGT----AGT), predicting a glycine-to-serine amino acid change.
|
2064725 |
1991 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Squamous cell carcinomas in psoralen-plus-ultraviolet A (PUVA) treated patients frequently exhibit p53 tumor suppressor genes and Ha-ras protooncogenes that are mutated at dipyrimidine sites and carry the ultraviolet fingerprint (i.e., C-to-T or CC-to-TT transitions).
|
12648234 |
2003 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A relatively high percentage (30%) of HRAS mutations was found in the keratoacanthomas compared with 13% in the squamous cell carcinomas.
|
2668964 |
1989 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Forty-two cases of squamous cell carcinoma arising in the upper aerodigestive tract were examined to determine the incidence and type of point mutation in codon 12 of the c-K-ras gene by using the polymerase chain reaction and oligonucleotide hybridization techniques on DNA extracted from paraffin blocks.
|
2064275 |
1991 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The aim of the study was to assess the frequency of Ha-ras oncogene mutations in cervical intraepithelial neoplasia (CIN) grade III and invasive squamous cell carcinomas and to examine this genetic factor in relation to HPV infection and the clinical evolution of cervical lesions.
|
12878090 |
2003 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Paraffin sections of 11 squamous cell carcinomas of the cheek pouch were used to detect mutated Ha-ras alleles.
|
1497802 |
1992 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Point mutations in codon 61 of the human Ha-ras gene were detected in the SCC, five of six analyzed actinic keratoses and in non-lesional epidermis of DMBA- and UVB-treated grafts, indicating that DMBA as well as UVB alone can induce these mutations in human skin.
|
11756239 |
2002 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our previous reports have shown that two thirds of 4-nitroquinoline-1-oxide (4NQO)-induced murine oral squamous cell carcinomas (SCC) have Hras1 mutations.
|
9294609 |
1997 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data complement recent findings that Ha-ras mutations are infrequent in oral squamous cell carcinomas among white caucasoid populations.
|
1403838 |
1992 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Multivariate analysis in patients who received adjuvant CRT for 1-3 ECEs (i.e., those with a favorable expected prognosis) identified the following adverse prognostic factors: 1) margin of < 5 mm for locoregional failure (66% versus 30%, P = 0.007) and DSS (42% versus 63%, P = 0.039); 2) HRAS mutation for distant failure (55% versus 25%, P = 0.007) and DSS (36% versus 63%, P = 0.024); and 3) TP53 DNA-binding domain missense mutations for DSS (52% versus 71%, P = 0.025) and overall survival (39% versus 61%, P = 0.007).We conclude that genetic information from NGS may improve the prognostic stratification offered by traditional prognosticators in resected OSCC patients with ECE.
|
27590518 |
2016 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutated ras genes have been found to be conspicuously absent from primary tumors of the esophagus, although high expression of ras p21 oncoprotein in some esophageal squamous cell carcinomas and mutations of the Ki- and Ha-ras genes in esophageal carcinoma cell lines have been reported.
|
8519418 |
1995 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A novel mutation in codon 6 of the Ki-ras gene was detected in a squamous cell carcinoma.
|
7916998 |
1994 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the present studies, we investigated the correlation between RASSF1A promoter methylation status and Kras2 mutations in 65 primary non small cell lung cancer (NSCLC) including 33 adenocarcinomas, 12 large cell carcinomas, and 20 squamous cell carcinomas.
|
14511407 |
2004 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population.
|
22294102 |
2012 |
|
Squamous cell carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to assess the frequency of Ha-ras oncogene mutations in cervical intraepithelial neoplasia (CIN) grade III and invasive squamous cell carcinomas and to examine this genetic factor in relation to HPV infection and the clinical evolution of cervical lesions.
|
12878090 |
2003 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Using Southern blot and ISH, c-myc and/or c-Ha-ras gene amplification was detected in 7/13 SCC tested.
|
8907200 |
1996 |
|
Squamous cell carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Functional kinomics identifies candidate therapeutic targets in head and neck cancer.
|
25125259 |
2014 |