|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations have been described in breast carcinomas under the headings of loss of heterozygosity (1p, 3p, 7q, 11p, 17p, 17 and 18q), mutations (p53, c-H-ras-1), and/or gene amplifications (c-myc, int-2/FGF3, and c-erbB-2/neu).
|
7671254 |
1995 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Approximately one fifth of the breast cancer patients in this analysis (disease-free and recurrent) expressed only a single oncogene marker (c-fos, c-myc, Ha-ras, or p53); one quarter of patients with recurrent disease expressed only one oncogene protein.
|
7794075 |
1995 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice.
|
12165863 |
2002 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated p21ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues, infiltration into lymphatic vessels and tumor recurrence.
|
10629074 |
2000 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since both estradiol treatment and ras-oncogene overexpression enhance tumorigenicity of hormone-dependent breast-cancer cells, we studied the effects of estrogen and of the activated v-Ha-ras oncogene on NK susceptibility of MCF-7 human breast-cancer cells.
|
1993553 |
1991 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Correlation with clinicopathological data showed, however, that the loss of one H-ras-1 allele in breast carcinoma DNAs is significantly linked to histological Grade III tumors, the lack of estrogen and/or progesterone receptors, and the subsequent occurrence of distal metastasis.
|
3524819 |
1986 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
|
15958052 |
2005 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The HRAS region of 11p is not the site of a primary alteration leading to breast cancer.
|
2406196 |
1990 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrate a direct (i) interaction of c-Ha-ras sequence with estrogen receptor and (ii) stimulatory effect of estrogen on c-Ha-ras gene transcription and suggest that alteration in transcriptional regulation of c-Ha-ras gene by estrogen may play an important role in progression of breast cancer.
|
10521493 |
1999 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that there is no overall association between rare alleles of the HRAS1 VNTR and breast cancer.
|
14693748 |
2003 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis.
|
9255581 |
1997 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distribution of Hras-1 oncogene alleles in BC did not significantly differ from that seen in healthy donors.
|
8416194 |
1993 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results obtained with atypical hyperplasia, a doubtful proliferating lesion, suggests that p21 c-Ha-ras protein expression is not restricted to breast carcinomas.
|
8003818 |
1994 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The frequency of rare c-Ha-ras-1 alleles and hence genotypes composed of two rare alleles was increased in the breast cancer population (P less than .001).
|
3462411 |
1986 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Secondly, 53 members of 3 families having a high incidence of breast cancer were c-Ha-ras-1 genotyped.
|
2668204 |
1989 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have proposed that rare Ha-ras alleles are markers of a genomic instability that predisposes to breast cancer.
|
7612910 |
1995 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Lod scores for close linkage of each candidate sequence to breast cancer were -19.6 for HRAS, -12.3 for KRAS2, -1.0 for NRAS, -6.0 for MYC, -6.1 for MYB, -8.2 for ERBA2, -7.9 for INT2, and -5.1 for RAF1.
|
2564734 |
1989 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transfection of Ha-RAS into MDA-MB-231 human breast cancer cells resulted in a significantly shorter cell doubling time compared with the controls.
|
15618232 |
2005 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggested that rare alleles at the HRAS1 VNTRs may contribute to breast cancer susceptibility.
|
21221763 |
2011 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The study was done on a total of 51 lung, colon and breast carcinoma tumors using a panel of oligonucleotides coding for the wild type and all possible mutations in codons 12 and 61 of c-K-ras gene.
|
3330777 |
1987 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have investigated the nature of the MspI site polymorphism at the c-Ha-ras VNTR observed in variety of tumors including breast cancer.We find that the MspI site 5' to the VNTR is present in a Non-B DNA structure with single-strand character that renders it accessible to bisulfite modification under native conditions, while the MspI site 3' to the VNTR appears to reside in a normal B-form structure that is inaccessible to bisulfite.
|
19129555 |
2009 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
|
19652463 |
2009 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There may be more common mutations in other genes (such as ATM, HRAS1) that confer a moderate risk of breast cancer, and may account for 5 to 15 per cent of cases.
|
8987214 |
1996 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study for the first time assayed the prognostic value and changes in the expression of SIRT3, LSP1, HRAS, SCUBE2 and AP2A2 genes in women with breast cancer in the Iranian population and findings confirmed potential biomarker and prognostic capability of these genes.
|
27165221 |
2016 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We analyzed 66 independent cases from sib pairs affected with breast cancer that had previously been collected during an investigation of pathogenetic-allele-sharing at the HRAS1 mini-satellite locus.
|
10464642 |
1999 |