|
Breast Carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Approximately one fifth of the breast cancer patients in this analysis (disease-free and recurrent) expressed only a single oncogene marker (c-fos, c-myc, Ha-ras, or p53); one quarter of patients with recurrent disease expressed only one oncogene protein.
|
7794075 |
1995 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Correlation with clinicopathological data showed, however, that the loss of one H-ras-1 allele in breast carcinoma DNAs is significantly linked to histological Grade III tumors, the lack of estrogen and/or progesterone receptors, and the subsequent occurrence of distal metastasis.
|
3524819 |
1986 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distinct mutation patterns of breast cancer-associated alleles of the HRAS1 minisatellite locus.
|
9949211 |
1999 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distribution of Hras-1 oncogene alleles in BC did not significantly differ from that seen in healthy donors.
|
8416194 |
1993 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated p21ras expression is associated with tumor aggressiveness in breast cancer including the extent of invasion into fat tissues, infiltration into lymphatic vessels and tumor recurrence.
|
10629074 |
2000 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Enhanced Ha-ras expression was documented in 66% of breast and 100% of colon carcinomas as compared with their normal counterparts, with levels in breast carcinomas ranging from 10.1 to 50.4 pg ras p21/micrograms protein and those in colon carcinomas ranging from 18.4 to 51.7 pg ras p21/micrograms protein.
|
3298786 |
1987 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice.
|
12165863 |
2002 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations have been described in breast carcinomas under the headings of loss of heterozygosity (1p, 3p, 7q, 11p, 17p, 17 and 18q), mutations (p53, c-H-ras-1), and/or gene amplifications (c-myc, int-2/FGF3, and c-erbB-2/neu).
|
7671254 |
1995 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical associations in human breast carcinomas.
|
2573420 |
1989 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
|
15958052 |
2005 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggested that rare alleles at the HRAS1 VNTRs may contribute to breast cancer susceptibility.
|
21221763 |
2011 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
|
19652463 |
2009 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Lod scores for close linkage of each candidate sequence to breast cancer were -19.6 for HRAS, -12.3 for KRAS2, -1.0 for NRAS, -6.0 for MYC, -6.1 for MYB, -8.2 for ERBA2, -7.9 for INT2, and -5.1 for RAF1.
|
2564734 |
1989 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
More common genes which are associated with an increased, but lower, risk of breast cancer are the ataxiatelangiectasia gene and the HRAS1 gene.
|
7547224 |
1995 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
No point mutations have been detected at the 12th codon of c-Ha-ras and c-Ki-ras in 40 and 65 breast cancer DNAs, respectively.
|
3293644 |
1988 |
|
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrate a direct (i) interaction of c-Ha-ras sequence with estrogen receptor and (ii) stimulatory effect of estrogen on c-Ha-ras gene transcription and suggest that alteration in transcriptional regulation of c-Ha-ras gene by estrogen may play an important role in progression of breast cancer.
|
10521493 |
1999 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results, adjusted for race and age, showed a positive overall association between the presence of rare HRAS alleles and breast cancer.
|
8385520 |
1993 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Point mutation at codon 12 of the Ki-ras gene in a primary breast carcinoma and the MDA-MB-134 human mammary carcinoma cell line.
|
2188722 |
1990 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis.
|
9255581 |
1997 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens.
|
17474063 |
2007 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Secondly, 53 members of 3 families having a high incidence of breast cancer were c-Ha-ras-1 genotyped.
|
2668204 |
1989 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several epidemiologic studies suggest that individuals carrying rare alleles at a minisatellite flanking the HRAS locus are at increased risk of cancer, including breast cancer.
|
8541881 |
1995 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since both estradiol treatment and ras-oncogene overexpression enhance tumorigenicity of hormone-dependent breast-cancer cells, we studied the effects of estrogen and of the activated v-Ha-ras oncogene on NK susceptibility of MCF-7 human breast-cancer cells.
|
1993553 |
1991 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility to breast cancer did not appear to be affected by the presence of rare HRAS1 alleles.
|
8589723 |
1996 |