|
Regional enteritis
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease.
|
28126021 |
2017 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.
|
24837172 |
2015 |
|
C4 complement assay (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.
|
23028341 |
2012 |
|
C4 complement assay (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.
|
23028341 |
2012 |
|
Systemic Scleroderma
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
|
Graft-vs-Host Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Elevated level of HSPA1L mRNA correlates with graft-versus-host disease.
|
25680846 |
2015 |
|
Sarcoidosis
|
0.030 |
Biomarker
|
disease |
LHGDN |
The HSP-70/Hom rs2075800 G allele frequency was higher in the sarcoid-uveitis group than in both the sarcoid-non-uveitis and control groups (83% vs. 71%, OR = 2.00, P(c) = 0.01; and 83% vs. 66%, OR = 2.45, P(c) = 0.00005, respectively).
|
17591867 |
2007 |
|
Sarcoidosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A strong association was found between HSP-70/Hom rs2075800 G and uveitis in patients with sarcoidosis.
|
17591867 |
2007 |
|
Graft-vs-Host Disease
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
HSP70-hom gene polymorphism as a prognostic marker of graft-versus-host disease.
|
17060867 |
2006 |
|
Sarcoidosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
HSP70-hom gene single nucleotide (+2763 G/A and +2437 C/T) polymorphisms in sarcoidosis.
|
16611259 |
2006 |
|
Graft-vs-Host Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In the present study, HSP70-hom polymorphism (+2763 G/A) was analyzed in the patients and donors of allogeneic HSCT in relation to transplantation outcome, susceptibility for generation of severe toxic lesions, and acute (a) graft-versus-host disease (GVHD).
|
15818324 |
2005 |
|
Ankylosing spondylitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, HSP70-hom locus analysis showed significantly increased frequency of A allele in the whole group of SpA (pC<0.05, OR=3.4), as well as in the groups with AS (pC<0.05, OR=5.6) and with uSpA (pC<0.05, OR=3.1), when compared with healthy controls.
|
11779758 |
2002 |
|
Ankylosing spondylitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
HSP70-1, HSP70-2 and HSP70-hom genotypes were analyzed by PCR-RFLP in patients with AS and in healthy controls.
|
9583810 |
1998 |
|
Sarcoidosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We screened the TNFA, TNFB, HSP70-1 and Hum70t genes around the class III region, as well as the HLA-DMA and -DMB genes in the class II region, for genetic polymorphism in sarcoidosis.
|
9349405 |
1997 |
|
Ankylosing spondylitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the HSP70-Hom polymorphic variation is not connected independently to the different pathogenesis of AS and ReA, as no statistically significant differences between the patient groups and/or controls could be found.
|
9098422 |
1994 |
|
Acute GVH disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the skin biopsies, HSPA1L mRNA expression was lower in patients with severe aGVHD (grades II-III) when compared to those with none or low grade aGVHD (grades 0-I) and normal controls.
|
25680846 |
2015 |
|
Malignant neoplasm of prostate
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our findings confirm the role of at-risk haplotype across the HSP70-hom/VEGF gene cluster in determining susceptibility to PCa.
|
20096741 |
2010 |
|
Prostate carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our findings confirm the role of at-risk haplotype across the HSP70-hom/VEGF gene cluster in determining susceptibility to PCa.
|
20096741 |
2010 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Since some factors may influence tumor progression rather than initiation, we also examined the relationship between the HSP70-hom polymorphism and the clinical characteristics of the malignancy at the time of diagnosis.
|
17578680 |
2008 |
|
Malignant neoplasm of prostate
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Given the role of the molecular chaperone HSP70 in the regulation of the androgen receptor (AR) transactivation function, we first chose to explore the association between the HSP70-hom functional genetic variant (+2437 T > C) and prostate cancer risk by genotyping DNA samples from 101 unselected PCa patients and 105 healthy men.
|
17578680 |
2008 |
|
Prostate carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Given the role of the molecular chaperone HSP70 in the regulation of the androgen receptor (AR) transactivation function, we first chose to explore the association between the HSP70-hom functional genetic variant (+2437 T > C) and prostate cancer risk by genotyping DNA samples from 101 unselected PCa patients and 105 healthy men.
|
17578680 |
2008 |
|
Acute GVH disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
HSP70-hom gene polymorphism in allogeneic hematopoietic stem-cell transplant recipients correlates with the development of acute graft-versus-host disease.
|
15818324 |
2005 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The authors designed a case-controlled study to investigate the potential association of the polymorphisms of TNF-alpha and of hsp70-2 and hsp70-hom genes with malignant tumors.
|
9338474 |
1997 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To investigate the effect of HSP70-hom+2437 single nucleotide polymorphisms (SNPs) on hypoxia and ischemia condition, we constructed the neuronal hypoxic injury model and the rat middle cerebral artery occlusion (MCAO) model to compare the inhibition rate of neurons and detect the infarct volume as well as the expression of related apoptotic proteins in order to explore the possible mechanisms.
|
31170438 |
2019 |
|
Hypertensive disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We carried out a case-control study among 367 coke oven workers in northwest China, focused on three common HSP70 polymorphisms (HSP70-1 G190C, HSP70-2 A1267G and HSP70-hom T2437C), and evaluated the association of HSP70 gene polymorphisms with work sites for high risk of hypertension.
|
30217924 |
2018 |