|
Absent reflex
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acute angle-closure glaucoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of variance revealed significant changes of antibody-level between certain time points (anti-HSP27 antibody [week 0 vs. 2], anti-TTLL12 antibody [week 0 vs. 12], and anti-NSE antibody [week 4 vs. 12] [P ≤ 0.05, respectively]) in AACG group.
|
27758063 |
2017 |
|
Acute exacerbation of chronic obstructive airways disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients.
|
31820266 |
2020 |
|
Acute flaccid paralysis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Desmin and HSP27, both indirectly regulate the contraction of muscle cells, were significantly downregulated as a result of EV71 infection, suggesting a link to acute flaccid paralysis.
|
21621020 |
2011 |
|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Different isoforms of Hsp27 have been found in lymphoid tissue of patients with acute lymphoblastic leukemia, and the protein has also been associated with viral infections.
|
8411230 |
1993 |
|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Heat shock 27 kDa protein 1 and other proteins that are highly expressed in ALL may play important roles in clinically distinguishing AML from ALL.
|
15501966 |
2004 |
|
Acute Myeloid Leukemia (AML-M2)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Discovery of epigenetically silenced genes in acute myeloid leukemias.
|
17330099 |
2007 |
|
Acute Myeloid Leukemia, M1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Discovery of epigenetically silenced genes in acute myeloid leukemias.
|
17330099 |
2007 |
|
Acute myelomonocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results support the theory that Hsp27 plays a contributory role in the pathogenesis of pediatric AML-M4/M5.
|
23404246 |
2013 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, NY intervention perturbed the course of AP via reduction of endoplasmic reticulum (ER) stress markers (BiP, IRE1 and Ero1-Lα), and molecular chaperones (Hsp27 and Hsp70).
|
30851439 |
2019 |
|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pro- and anti-inflammatory cytokines and the stress proteins Hsp27 and Hsp60 with proposed anti- and pro-inflammatory properties, respectively, were measured by two-site ELISA in the serum of patients with aggressive periodontitis (AgP, n = 30), chronic periodontitis (CP, n = 29) and periodontally healthy controls (H, n = 28).
|
29766408 |
2018 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Gender-related differences were observed and HSP27 expression was higher in poorly-differentiated adenocarcinomas than in well-differentiated forms.
|
15013707 |
2004 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
LHGDN |
Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response.
|
19088045 |
2008 |
|
Adenocarcinoma
|
0.080 |
Biomarker
|
group |
BEFREE |
Here, we report that human adenocarcinoma cells (MCF-7) survive UV-induced DNA damage by heat shock protein 27 (Hsp27)-assisted Akt/p21 phosphorylation/translocation.
|
20858736 |
2010 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
However, Hsp27 expression was markedly lower in Barrett's metaplasia and oesophageal adenocarcinomas.
|
10027336 |
1999 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
In certain tumours of glandular origin (such as oesophageal adenocarcinomas), the level of Hsp27 is decreased.
|
25230790 |
2015 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
However, no significant difference in hsp27 protein expression was found between cervical glandular intraepithelial neoplasia and invasive adenocarcinoma.
|
15882177 |
2005 |
|
Adenocarcinoma
|
0.080 |
Biomarker
|
group |
BEFREE |
ERalpha gene expression at the mRNA level significantly correlated with the immunoprofile of the estrogen-inducible HSP27 protein in androgen-insensitive prostatic adenocarcinomas.
|
10960840 |
2000 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
LHGDN |
Gender-related differences were observed and HSP27 expression was higher in poorly-differentiated adenocarcinomas than in well-differentiated forms.
|
15013707 |
2004 |
|
Adenocarcinoma
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We performed a comprehensive investigation of HSP and GRP expression including HSP27, phosphorylated (p)-HSP27((Ser15)), p-HSP27((Ser78)), p-HSP27((Ser82)), HSP60, HSP70, HSP90, GRP78 and GRP94 in 92 primary resected oesophageal adenocarcinomas by using reverse phase protein arrays (RPPA), immunohistochemistry (IHC) and real-time quantitative RT-PCR (qPCR).
|
22911792 |
2012 |
|
Adenocarcinoma Of Esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate abundant constitutive expression of the stress-response protein Hsp27 in the normal oesophagus, and suggest that low-level expression in Barrett's metaplasia may be one factor which may influence susceptibility to oesophageal adenocarcinoma development.
|
10027336 |
1999 |
|
Adenocarcinoma Of Esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma.
|
30746368 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
Biomarker
|
disease |
CTD_human |
Comparative proteome analysis of human adenocarcinoma.
|
19381893 |
2010 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
Biomarker
|
disease |
BEFREE |
These data indicate that ERp29 affects lung adenocarcinoma cell chemosensitivity to gemcitabine by regulating phosphorylated HSP27.
|
30651868 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the inhibitory effect of a small interfering (si) RNA on the expression of HSP27 gene in the TRAIL-resistant human lung adenocarcinoma cell line A549, and the effect of HSP27 siRNA on drug sensitization of A549 cells to TRAIL treatment.
|
19540014 |
2010 |