|
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
|
0.760 |
Biomarker
|
disease |
BEFREE |
Mutations in the small heat shock protein HSPB1 (HSP27) are a cause of axonal Charcot-Marie-Tooth neuropathy (CMT2F) and distal hereditary motor neuropathy.
|
23728742 |
2013 |
|
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
|
0.760 |
GeneticVariation
|
disease |
BEFREE |
One variant of CMT, 2F, is characterized by mutations in heat shock protein 27 (Hsp27).
|
29133339 |
2018 |
|
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
|
0.760 |
GeneticVariation
|
disease |
BEFREE |
Recently, mutations in both the small heat shock protein 27 (HSP27 or HSPB1) and 22 (HSP22 or HSPB8) genes have been reported to cause autosomal dominant CMT with minimal sensory involvement (CMT 2F/CMT2L) and autosomal dominant distal hereditary motor neuropathy type II (dHMN II).
|
18832141 |
2008 |
|
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
|
0.760 |
Biomarker
|
disease |
BEFREE |
Mutations in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1) have been reported in association with Charcot-Marie-Tooth disease type 2F or dHMN type II.
|
20870250 |
2010 |
|
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
|
0.760 |
GeneticVariation
|
disease |
BEFREE |
Mutations in heat shock 27 kDa protein 1 (HSP27 or HSPB1) cause distal hereditary motor neuropathy (dHMN) or Charcot-Marie-Tooth disease type 2 F (CMT2F) according to unknown factors.
|
26141737 |
2015 |
|
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
|
0.760 |
GeneticVariation
|
disease |
BEFREE |
Recently, mutations in the small heat shock protein 27 (HSP27) gene were found to cause dHMN type II or Charcot-Marie-Tooth disease type 2F (CMT2F).
|
18587268 |
2008 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hsp27 was upregulated in HCC tissues, and Hsp27 overexpression significantly facilitated formation of HCC cell colony and invasion in normoxia and tolerance in hypoxia by interacting with HIF-1α.
|
26381739 |
2015 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also demonstrated that Hsp27 inhibits cisplatin- induced HCC cell death through autophagy activation.
|
21888831 |
2011 |
|
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our results strongly suggest that activation of PKCdelta regulates the phosphorylation of HSP27 via p38 MAPK in human HCC.
|
17673262 |
2007 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This meta-analysis revealed that HSP27 may play a key role in the development of HCC and could be a reliable biomarker for the prognosis of patients with HCC.
|
29563808 |
2018 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, this study reveals the important role of this PKC beta-ERK(1/2)/p38MAPK-HSP27 pathway, which was verified for the first time, in modulating HCC cell motility and invasion.
|
18167130 |
2008 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous study indicated that Hsp27 might be an important biomarker in hepatocellular carcinoma (HCC).
|
28903396 |
2017 |
|
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HSP27 expression levels are associated with the sensitivity of hepatocellular carcinoma cells to 17-allylamino-17-demethoxygeldanamycin.
|
23469976 |
2013 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 27(HSP27) is confirmed as an apoptosis regulator, but its antiapoptotic mechanism in metastatic hepatocellular carcinoma (HCC) cells remains unclear.
|
19331697 |
2009 |
|
Malignant tumor of colon
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
HSP27 protein levels in several human colon cancer cell lines (LoVo, HCT15, WiDr, HCT116, HT-29 and SW480) were determined by immunoblot and densitometry analysis.
|
18949417 |
2008 |
|
Malignant tumor of colon
|
0.360 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-214 sensitizes colon cancer cells to 5-FU by targeting Hsp27, indicating a significant role for this miRNA in colon cancer chemotherapy.
|
30915129 |
2019 |
|
Malignant tumor of colon
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Tissue array results showed that colon cancer patients with high expression of HSP27 exhibited poor prognosis.
|
30544747 |
2018 |
|
Malignant tumor of colon
|
0.360 |
Biomarker
|
disease |
BEFREE |
Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines.
|
26043026 |
2015 |
|
Malignant tumor of colon
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the suppression of HSP27 expression in colon cancer cells may promote 5-FU sensitivity by inducing apoptosis, despite the acceleration in 5-FU metabolism.
|
22842517 |
2012 |
|
Malignant tumor of colon
|
0.360 |
Biomarker
|
disease |
BEFREE |
Although further research is warranted, the present study confirmed that concurrent treatment with Hsp27 knockdown using apatorsen and 5-FU could be a promising therapy for colon cancer.
|
29328475 |
2018 |
|
Squamous cell carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In patients with cervical cancer, Hsp27 is predominantly expressed in well-differentiated and moderately differentiated squamous cell carcinomas.
|
8411230 |
1993 |
|
Squamous cell carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Attenuation of Hsp27 expression was accomplished by antisense or RNAi (interfering RNA) strategies in SQ20B head-and-neck squamous carcinoma, PC3 prostate cancer, and U87 glioblastoma radioresistant cells.
|
17980509 |
2008 |
|
Squamous cell carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line.
|
9210326 |
1997 |
|
Malignant neoplasm of stomach
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
High expression of hsp27 and hsp70 in breast, endometrial and gastric cancers has been associated with metastasis, poor prognosis and resistance to chemo- or radiotherapy.
|
14604899 |
2004 |
|
Malignant neoplasm of stomach
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In addition, expression of Hsp27 seems to be a negative prognostic factor for gastric cancer.
|
8411230 |
1993 |