|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge.
|
31820266 |
2020 |
|
Acute exacerbation of chronic obstructive airways disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients.
|
31820266 |
2020 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, NY intervention perturbed the course of AP via reduction of endoplasmic reticulum (ER) stress markers (BiP, IRE1 and Ero1-Lα), and molecular chaperones (Hsp27 and Hsp70).
|
30851439 |
2019 |
|
Chest Pain
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Using two-dimensional electrophoresis and immunoblotting, we observed that heat-shock protein 27 (HSPB1) levels and phosphorylation are significantly increased in platelets of twelve patients with myocardial infarction compared to patients with nonischemic chest pain (6.4 ± 1.0-fold versus 1.0 ± 0.9-fold and 5.9 ± 1.8-fold versus 1.0 ± 0.8-fold; <i>p</i> < 0.05).
|
31783528 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve was applied to assess the diagnostic performance of HSP27 in CHD.
|
29232010 |
2019 |
|
Drug abuse
|
0.010 |
AlteredExpression
|
group |
BEFREE |
On the other hand, increased HSP27, pHSP27 and Trx-1 expression in the right ventricle by ethanol + MDMA could be a protective mechanism to reduce the adverse effects of oxidative stress caused by both drugs of abuse.
|
30708098 |
2019 |
|
Enterovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation.
|
30814282 |
2019 |
|
Hepatitis C
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, DNA constructs encoding HCV NS3 and heat shock protein 27 (Hsp27)-NS3 genes, and the recombinant (r) NS3 and rHsp27-NS3 proteins complexed with HR9 and Cady-2 cell penetrating peptides (CPPs) were utilized to evaluate antibody, cytokine and Granzyme B secretion in mice.
|
31254535 |
2019 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Generally, Hsp20 was identified as a novel anti-HCV, anti-HSV and anti-HIV agent, but Hsp27 was efficient in the suppression of HSV infection.
|
31362669 |
2019 |
|
Myocarditis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study tested the hypothesis that heat shock protein B1 (HSPB1), which limits myocardial inflammation during endotoxemia, modulates wound healing after MI.
|
29982352 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
The most widely studied HSPs in SAH are HSP70, haeme oxygenase-1 (HO-1), HSP20 and HSP27.
|
31273911 |
2019 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data indicated that HSPB1 mRNA low expression was correlated to better overall survival (OS) for all NSCLC patients, hazard ratio (HR) 1.41 (1.24-1.61), p=1.1e-7, and better OS in lung adenocarcinoma (LUAD) patients, HR 1.81 (1.42-2.32), p=1.5e-06, but not in lung squamous cell carcinoma (LUSC) patients, HR 1.21 (0.94-1.55), p=0.14.
|
29017331 |
2019 |
|
Hepatoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, O-GlcNAcylation modification of HSPB1 promoted proliferation and enhanced the chemotherapeutic resistance of HB cell lines in vitro.
|
31637018 |
2019 |
|
Radiation esophagitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of single nucleotide polymorphisms at HSPB1 rs7459185 and TGFB1 rs11466353 with radiation esophagitis in lung cancer.
|
31015163 |
2019 |
|
Endotoxemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
This study tested the hypothesis that heat shock protein B1 (HSPB1), which limits myocardial inflammation during endotoxemia, modulates wound healing after MI.
|
29982352 |
2019 |
|
Motor symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This review extensively profiles the published literature on CMT2F and distal hereditary motor neuropathy II (dHMN II), a similar neuropathy with exclusively motor symptoms that is also due to mutations in Hsp27.
|
31212070 |
2019 |
|
Tumor Initiation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this work, we demonstrated that ESCC cell lines in spheroid culture display CSC phenotypes, including increased ALDH activity, chemoresistance and tumor initiation, which are dependent on Hsp27 activation.
|
30920655 |
2019 |
|
skin damage
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Management the expression of hsp27 can be used as a potential intervention method to alleviate UVB-induced skin damage.
|
30902393 |
2019 |
|
Photodermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS These findings complemented the mechanism of skin photodamage and demonstrated the photoprotective mechanisms of Hsp27 in HaCaT cells, which might implicate a potential therapeutic target of photodamage and photodermatosis.
|
31592001 |
2019 |
|
Familial multiple trichoepitheliomata
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EAC between 1990 and 2007 at two university hospitals.
|
30746368 |
2019 |
|
Atherosclerotic lesion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Given that increased expression of HSP27 is inversely correlated with CVD risk, our findings suggest that 4-PBA protects against the early stages of atherogenesis in part by enhancing HSP27 levels, leading to inhibition of both macrophage cell death and monocyte-macrophage differentiation.-Lynn, E. G., Lhoták, Š., Lebeau, P., Byun, J. H., Chen, J., Platko, K., Shi, C., O'Brien, E. R., Austin, R. C. 4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of <i>Apoe<sup>-/-</sup></i> mice.
|
30964709 |
2019 |
|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pro- and anti-inflammatory cytokines and the stress proteins Hsp27 and Hsp60 with proposed anti- and pro-inflammatory properties, respectively, were measured by two-site ELISA in the serum of patients with aggressive periodontitis (AgP, n = 30), chronic periodontitis (CP, n = 29) and periodontally healthy controls (H, n = 28).
|
29766408 |
2018 |
|
Primary Myelofibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that HSP27 plays a key role in the pathophysiology of myelofibrosis and represents a new potential therapeutic target for patients with myeloproliferative neoplasms.
|
29650953 |
2018 |
|
Bloom Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
BLM+ADSC-14d vs BLM significantly decreased Hsp27 (P=0.028), IL-6 (P=0.013), Col4 (P=0.002), and increased Nfkβ (P=0.040) and Tgfβ1 (P=0.002).
|
29167193 |
2018 |
|
Cerebral Palsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study provides the first evidence that Hsp27 may be differentially expressed and regulated in AgP patients as compared with CP patients and healthy individuals.
|
29766408 |
2018 |