|
Carcinogenesis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
HSP70 is also an important part of this family and whether the alterations of HSP10 and HSP70 expression and their common expression correlates with carcinogenesis and progression of nasopharyngeal carcinoma (NPC) has not been reported.
|
31564980 |
2019 |
|
Mycobacterium Infections
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We report here the mapping of T-cell-stimulatory determinants of the GroES 10-kDa heat shock protein homologues from Mycobacterium leprae and Mycobacterium tuberculosis, which are known as major immunogens in mycobacterial infections.
|
9746595 |
1998 |
|
Spastic Paraplegia, Hereditary
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
|
11898127 |
2002 |
|
Pancreatic carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CPN group included patients who were diagnosed with unresectable PC and underwent fluoroscopically guided bilateral CPN (10 mL dehydrated alcohol each side) once between January 1, 2006, and December 31, 2013.
|
28339435 |
2017 |
|
Pemphigus and fogo selvagem
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We previously described a new variant of endemic pemphigus foliaceus in El Bagre, Colombia (El Bagre-EPF).
|
29152726 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CPN group included patients who were diagnosed with unresectable PC and underwent fluoroscopically guided bilateral CPN (10 mL dehydrated alcohol each side) once between January 1, 2006, and December 31, 2013.
|
28339435 |
2017 |
|
ovarian neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CGC HSPE-1 haplotype associates with stage in ovarian cancer.
|
17419711 |
2007 |
|
Malignant neoplasm of ovary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CGC HSPE-1 haplotype associates with stage in ovarian cancer.
|
17419711 |
2007 |
|
Mitochondrial enzyme deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We have screened three candidate patient groups for variations in the HSPD1 and HSPE1 genes encoding the mitochondrial Hsp60/Hsp10 chaperone complex: two patients with multiple mitochondrial enzyme deficiency, 61 sudden infant death syndrome cases (MIM: #272120), and 60 patients presenting with ethylmalonic aciduria carrying non-synonymous susceptibility variations in the ACADS gene (MIM: *606885 and #201470).
|
17072495 |
2007 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CGC HSPE-1 haplotype associates with stage in ovarian cancer.
|
17419711 |
2007 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
To address the issue of epitope recognition in mycobacterial diseases, we have analysed 16 peptides (15-mer peptides) spanning the entire ML and M. tuberculosis GroES protein in leprosy (n = 19) and tuberculosis (n = 9) patients and healthy endemic controls (n = 8).
|
15056384 |
2004 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that Mt cpn10 may be a valuable pharmacological target for the clinical therapy of vertebral tuberculosis and possibly other bone diseases.
|
9334363 |
1997 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
This study describes the intricate architecture of a complex multicistronic alr-groEL1 operon, harboring essential genes, namely tsaD, tsaB, tsaE, groES, groEL1, and alr (required for cell wall synthesis), and rimI encoding an N-α- acetyltransferase in Mycobacterium tuberculosis.
|
28256563 |
2017 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
We sought to determine whether slow off-rate modified aptamer (SOMAmer) reagents with subnanomolar affinity for <i>Mycobacterium tuberculosis</i> proteins (antigens 85A, 85B, 85C, GroES, GroEL2, DnaK, CFP10, KAD, CFP2, RplL, and Tpx) could be useful to diagnose tuberculosis.
|
28794178 |
2017 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Peripheral blood mononuclear cells (PBMC) from treated tuberculoid leprosy or lepromatous leprosy patients and from healthy household or hospital staff contacts of the patients were cultured with 20 16-mer peptides covering the entire sequences of both M. leprae and M. tuberculosis GroES.
|
9746595 |
1998 |
|
Tuberculosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
In this study, we show that M. tuberculosis HrcA is able to bind to its cognate CIRCE DNA element present in the upstream regions of groES and groEL2 operons only with the help of other protein(s).
|
31765672 |
2020 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
We suggest the further examination, by molecular and genetic studies, of the role of HSP60 and HSP10 during carcinogenesis of the prostate as well as of other organs.
|
12820390 |
2003 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Hsp10 and Hsp90 may be involved in large bowel carcinogenesis.
|
25075042 |
2014 |
|
Astrocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma.
|
31564980 |
2019 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The sequence data confirm the existence of highly conserved structures, which could be functionally important for the concerted action of GroEL and GroES in the folding and assembly of other proteins, and possibly in the initiation of autoimmune diseases.
|
7538307 |
1995 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In this article, we present an overview of various aspects of Hsp10 and EPF as they participate in physiological and pathological processes such as the antitumor response and autoimmune diseases.
|
19913561 |
2010 |
|
Mycobacterium Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
To address the issue of epitope recognition in mycobacterial diseases, we have analysed 16 peptides (15-mer peptides) spanning the entire ML and M. tuberculosis GroES protein in leprosy (n = 19) and tuberculosis (n = 9) patients and healthy endemic controls (n = 8).
|
15056384 |
2004 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Hsp10 is involved in immunomodulation and tumor progression.
|
25075042 |
2014 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Evolutionarily, HSP10 is also reported to be involved in immunomodulation and tumor progression.
|
29028811 |
2017 |
|
Childhood Astrocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma.
|
31564980 |
2019 |