Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary 		0.300 Therapeutic group CTD_human Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. 12967636 2003
CUI: C0036529
Disease: Myocardial Diseases, Secondary
Myocardial Diseases, Secondary 		0.300 Therapeutic group CTD_human Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. 12967636 2003
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.300 Therapeutic group CTD_human These data provide a novel link between Hsp10/Hsp60 and cardiac protection in doxorubicin cardiomyopathy. 12967636 2003
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE In this study, we show that M. tuberculosis HrcA is able to bind to its cognate CIRCE DNA element present in the upstream regions of groES and groEL2 operons only with the help of other protein(s). 31765672 2020
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE This study describes the intricate architecture of a complex multicistronic alr-groEL1 operon, harboring essential genes, namely tsaD, tsaB, tsaE, groES, groEL1, and alr (required for cell wall synthesis), and rimI encoding an N-α- acetyltransferase in Mycobacterium tuberculosis. 28256563 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE We sought to determine whether slow off-rate modified aptamer (SOMAmer) reagents with subnanomolar affinity for <i>Mycobacterium tuberculosis</i> proteins (antigens 85A, 85B, 85C, GroES, GroEL2, DnaK, CFP10, KAD, CFP2, RplL, and Tpx) could be useful to diagnose tuberculosis. 28794178 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE To address the issue of epitope recognition in mycobacterial diseases, we have analysed 16 peptides (15-mer peptides) spanning the entire ML and M. tuberculosis GroES protein in leprosy (n = 19) and tuberculosis (n = 9) patients and healthy endemic controls (n = 8). 15056384 2004
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE Peripheral blood mononuclear cells (PBMC) from treated tuberculoid leprosy or lepromatous leprosy patients and from healthy household or hospital staff contacts of the patients were cultured with 20 16-mer peptides covering the entire sequences of both M. leprae and M. tuberculosis GroES. 9746595 1998
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE Our findings suggest that Mt cpn10 may be a valuable pharmacological target for the clinical therapy of vertebral tuberculosis and possibly other bone diseases. 9334363 1997
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 GeneticVariation phenotype BEFREE HSP70 is also an important part of this family and whether the alterations of HSP10 and HSP70 expression and their common expression correlates with carcinogenesis and progression of nasopharyngeal carcinoma (NPC) has not been reported. 31564980 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE Hsp10 and Hsp90 may be involved in large bowel carcinogenesis. 25075042 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE We suggest the further examination, by molecular and genetic studies, of the role of HSP60 and HSP10 during carcinogenesis of the prostate as well as of other organs. 12820390 2003
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 Biomarker disease BEFREE In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. 31564980 2019
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 Biomarker disease BEFREE In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. 31564980 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 AlteredExpression phenotype BEFREE PGAM1 and HSPE1 showed higher expressions in PDAC tissue with clinical metastasis and highly metastatic pancreatic cancer cell lines PC-1.0 and Aspc-1. 29922073 2018
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 AlteredExpression disease BEFREE So far, whether the expression of HSP10 or c-PARP is associated with clinicopathologic implication for astrocytoma has not been reported. 29028811 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Evolutionarily, HSP10 is also reported to be involved in immunomodulation and tumor progression. 29028811 2017
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.020 AlteredExpression disease BEFREE So far, whether the expression of HSP10 or c-PARP is associated with clinicopathologic implication for astrocytoma has not been reported. 29028811 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Hsp10 is involved in immunomodulation and tumor progression. 25075042 2014
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.020 Biomarker group BEFREE In this article, we present an overview of various aspects of Hsp10 and EPF as they participate in physiological and pathological processes such as the antitumor response and autoimmune diseases. 19913561 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 AlteredExpression phenotype LHGDN Our data show that the expression of HSP60, in both primary tumour and lymph node metastasis, is correlated with the tumoral grade, while the HSP10 expression is not. 16253146 2005
CUI: C0026918
Disease: Mycobacterium Infections
Mycobacterium Infections 		0.020 Biomarker group BEFREE To address the issue of epitope recognition in mycobacterial diseases, we have analysed 16 peptides (15-mer peptides) spanning the entire ML and M. tuberculosis GroES protein in leprosy (n = 19) and tuberculosis (n = 9) patients and healthy endemic controls (n = 8). 15056384 2004
CUI: C0026918
Disease: Mycobacterium Infections
Mycobacterium Infections 		0.020 GeneticVariation group BEFREE We report here the mapping of T-cell-stimulatory determinants of the GroES 10-kDa heat shock protein homologues from Mycobacterium leprae and Mycobacterium tuberculosis, which are known as major immunogens in mycobacterial infections. 9746595 1998
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.020 Biomarker group BEFREE The sequence data confirm the existence of highly conserved structures, which could be functionally important for the concerted action of GroEL and GroES in the folding and assembly of other proteins, and possibly in the initiation of autoimmune diseases. 7538307 1995
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 Biomarker disease BEFREE In our previous study, we found HSP10 correlates with poor prognosis of oral squamous cell carcinoma and astrocytoma. 31564980 2019